Isopeptide bond: Difference between revisions
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==Formation== | ==Formation== | ||
==Spontaneous== | ==Spontaneous== | ||
Some isopeptide bonds appear to form spontaneously during protein folding. These include the intramolecular isopeptide bonds in pilin monomers<ref name="kang2009" />, and the "chain mail" isopeptide bonds in the capsid of | Some isopeptide bonds appear to form spontaneously during protein folding. These include the intramolecular isopeptide bonds in pilin monomers<ref name="kang2009" />, and the "chain mail" isopeptide bonds in the capsid of bacteriophage HK97<ref name="wikoff2000" />. | ||
===Enzymatic=== | ===Enzymatic=== | ||
Inter-molecular isopeptide bonds that link bacterial pilins into lengthy pili are formed enzymatically by a cysteine transpeptidase "sortase"<ref name="kang2009">PMID: 19497855</ref>. However, the same pilins have multiple intra-molecular isopeptide bonds that appear to form spontaneously<ref name="kang2009" />. | Inter-molecular isopeptide bonds that link bacterial pilins into lengthy pili are formed enzymatically by a cysteine transpeptidase "sortase"<ref name="kang2009">PMID: 19497855</ref>. However, the same pilins have multiple intra-molecular isopeptide bonds that appear to form spontaneously<ref name="kang2009" />. | ||
