1efk: Difference between revisions

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[[Image:1efk.gif|left|200px]]
{{Seed}}
[[Image:1efk.png|left|200px]]


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{{STRUCTURE_1efk|  PDB=1efk  |  SCENE=  }}  
{{STRUCTURE_1efk|  PDB=1efk  |  SCENE=  }}  


'''STRUCTURE OF HUMAN MALIC ENZYME IN COMPLEX WITH KETOMALONATE'''
===STRUCTURE OF HUMAN MALIC ENZYME IN COMPLEX WITH KETOMALONATE===




==Overview==
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Malic enzymes are widely distributed in nature and have many biological functions. The crystal structure of human mitochondrial NAD(P)+-dependent malic enzyme in a quaternary complex with NAD+, Mn++ and oxalate has been determined at 2.2 A resolution. The structures of the quaternary complex with NAD+, Mg++, tartronate or ketomalonate have been determined at 2.6 A resolution. The structures show the enzyme in a closed form in these complexes and reveal the binding modes of the cation and the inhibitors. The divalent cation is coordinated in an octahedral fashion by six ligating oxygens, two from the substrate/inhibitor, three from Glu 255, Asp 256 and Asp 279 of the enzyme, and one from a water molecule. The structural information has significant implications for the catalytic mechanism of malic enzymes and identifies Tyr 112 and Lys 183 as possible catalytic residues. Changes in tetramer organization of the enzyme are also observed in these complexes, which might be relevant for its cooperative behavior and allosteric control.
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{{ABSTRACT_PUBMED_10700286}}


==About this Structure==
==About this Structure==
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[[Category: Malic enzyme]]
[[Category: Malic enzyme]]
[[Category: Quaternary complex]]
[[Category: Quaternary complex]]
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Revision as of 21:37, 30 June 2008

File:1efk.png

Template:STRUCTURE 1efk

STRUCTURE OF HUMAN MALIC ENZYME IN COMPLEX WITH KETOMALONATE

Template:ABSTRACT PUBMED 10700286

About this Structure

1EFK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of a closed form of human malic enzyme and implications for catalytic mechanism., Yang Z, Floyd DL, Loeber G, Tong L, Nat Struct Biol. 2000 Mar;7(3):251-7. PMID:10700286

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