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==Solution structure of a Eosinophil Cationic Protein-trisaccharide heparin mimetic complex==
==Solution structure of a Eosinophil Cationic Protein-trisaccharide heparin mimetic complex==
<StructureSection load='2lvz' size='340' side='right'caption='[[2lvz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2lvz' size='340' side='right'caption='[[2lvz]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2lvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LVZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2lvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LVZ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=LVZ:PROPAN-2-YL+2-DEOXY-6-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSIDE'>LVZ</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IDS:2-O-SULFO-ALPHA-L-IDOPYRANURONIC+ACID'>IDS</scene>, <scene name='pdbligand=LVZ:PROPAN-2-YL+2-DEOXY-6-O-SULFO-2-(SULFOAMINO)-ALPHA-D-GLUCOPYRANOSIDE'>LVZ</scene>, <scene name='pdbligand=SGN:N,O6-DISULFO-GLUCOSAMINE'>SGN</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RNASE3, ECP, RNS3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lvz OCA], [https://pdbe.org/2lvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lvz RCSB], [https://www.ebi.ac.uk/pdbsum/2lvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lvz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lvz OCA], [https://pdbe.org/2lvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lvz RCSB], [https://www.ebi.ac.uk/pdbsum/2lvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lvz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ECP_HUMAN ECP_HUMAN]] Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.<ref>PMID:2501794</ref> <ref>PMID:19450231</ref>
[https://www.uniprot.org/uniprot/ECP_HUMAN ECP_HUMAN] Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.<ref>PMID:2501794</ref> <ref>PMID:19450231</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Angulo, J]]
[[Category: Angulo J]]
[[Category: Barbero, J Jimenez]]
[[Category: Boix E]]
[[Category: Boix, E]]
[[Category: Bruix M]]
[[Category: Bruix, M]]
[[Category: Canales A]]
[[Category: Canales, A]]
[[Category: Diaz D]]
[[Category: Diaz, D]]
[[Category: Garcia Mayoral M]]
[[Category: Mayoral, M Garcia]]
[[Category: Jimenez Barbero J]]
[[Category: Moussaoui, M]]
[[Category: Lopez Prados J]]
[[Category: Nieto, P]]
[[Category: Moussaoui M]]
[[Category: Paz, J de]]
[[Category: Nieto P]]
[[Category: Prados, J Lopez]]
[[Category: De Paz J]]
[[Category: Heparin]]
[[Category: Hydrolase]]
[[Category: Molecular recognition]]
Retrieved from "https://proteopedia.org/2lvz"