2m2e: Difference between revisions

<StructureSection load='2m2e' size='340' side='right'caption='[[2m2e]]' scene=''>

<table><tr><td colspan='2'>[[2m2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M2E FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m2e OCA], [https://pdbe.org/2m2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m2e RCSB], [https://www.ebi.ac.uk/pdbsum/2m2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m2e ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/DNJC2_HUMAN DNJC2_HUMAN] Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation. Specifically binds DNA sequence 5'-GTCAAGC-3'.<ref>PMID:16002468</ref> <ref>PMID:15802566</ref> <ref>PMID:21179169</ref>  

[[Category: Homo sapiens]]

[[Category: Arrowsmith C]]

[[Category: Garcia M]]

[[Category: Houliston S]]

[[Category: Lemak A]]

[[Category: Montelione GT]]

[[Category: Ong M]]

[[Category: Yee A]]