1eh2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 1: Line 1:
[[Image:1eh2.gif|left|200px]]
{{Seed}}
[[Image:1eh2.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1eh2|  PDB=1eh2  |  SCENE=  }}  
{{STRUCTURE_1eh2|  PDB=1eh2  |  SCENE=  }}  


'''STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15, NMR, 20 STRUCTURES'''
===STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15, NMR, 20 STRUCTURES===




==Overview==
<!--  
Eps15 homology (EH) domains are eukaryotic signaling modules that recognize proteins containing Asn-Pro-Phe (NPF) sequences. The structure of the central EH domain of Eps15 has been solved by heteronuclear magnetic resonance spectroscopy. The fold consists of a pair of EF hand motifs, the second of which binds tightly to calcium. The NPF peptide is bound in a hydrophobic pocket between two alpha helices, and binding is mediated by a critical aromatic interaction as revealed by structure-based mutagenesis. The fold is predicted to be highly conserved among 30 identified EH domains and provides a structural basis for defining EH-mediated events in protein trafficking and growth factor signaling.
The line below this paragraph, {{ABSTRACT_PUBMED_9721102}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 9721102 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_9721102}}


==About this Structure==
==About this Structure==
1EH2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EH2 OCA].  
1EH2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EH2 OCA].  


==Reference==
==Reference==
Line 32: Line 36:
[[Category: Npf binding]]
[[Category: Npf binding]]
[[Category: Signaling domain]]
[[Category: Signaling domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:05:34 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:41:15 2008''

Revision as of 21:41, 30 June 2008

File:1eh2.png

Template:STRUCTURE 1eh2

STRUCTURE OF THE SECOND EPS15 HOMOLOGY DOMAIN OF HUMAN EPS15, NMR, 20 STRUCTURES

Template:ABSTRACT PUBMED 9721102

About this Structure

1EH2 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain., de Beer T, Carter RE, Lobel-Rice KE, Sorkin A, Overduin M, Science. 1998 Aug 28;281(5381):1357-60. PMID:9721102

Page seeded by OCA on Tue Jul 1 00:41:15 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=1eh2&oldid=592314"