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<StructureSection load='4hbq' size='340' side='right'caption='[[4hbq]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='4hbq' size='340' side='right'caption='[[4hbq]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hbq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HBQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[4hd9|4hd9]], [[4hcr|4hcr]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MADCAM1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbq OCA], [https://pdbe.org/4hbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbq RCSB], [https://www.ebi.ac.uk/pdbsum/4hbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hbq OCA], [https://pdbe.org/4hbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hbq RCSB], [https://www.ebi.ac.uk/pdbsum/4hbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hbq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN]] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.  
[https://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Springer, T]]
[[Category: Springer T]]
[[Category: Yu, Y]]
[[Category: Yu Y]]
[[Category: Zhu, J]]
[[Category: Zhu J]]
[[Category: Immune system]]
[[Category: Immunoglobulin superfamily]]
[[Category: Integrin alpha4beta7]]

Revision as of 06:37, 2 March 2023

Crystal structure of a loop deleted mutant of Human MAdCAM-1 D1D2

4hbq, resolution 1.40Å

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