2mh2: Difference between revisions
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==Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2== | ==Structural insights into the DNA recognition and protein interaction domains reveal fundamental homologous DNA pairing properties of HOP2== | ||
<StructureSection load='2mh2' size='340' side='right'caption='[[2mh2 | <StructureSection load='2mh2' size='340' side='right'caption='[[2mh2]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2mh2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MH2 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mh2 OCA], [https://pdbe.org/2mh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mh2 RCSB], [https://www.ebi.ac.uk/pdbsum/2mh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mh2 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mh2 OCA], [https://pdbe.org/2mh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mh2 RCSB], [https://www.ebi.ac.uk/pdbsum/2mh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mh2 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/HOP2_MOUSE HOP2_MOUSE] Plays an important role in meiotic recombination. Stimulates DMC1-mediated strand exchange required for pairing homologous chromosomes during meiosis. The complex PSMC3IP/MND1 binds DNA, stimulates the recombinase activity of DMC1 as well as DMC1 D-loop formation from double-strand DNA. This complex stabilizes presynaptic RAD51 and DMC1 filaments formed on single strand DNA to capture double-strand DNA. This complex stimulates both synaptic and presynaptic critical steps in RAD51 and DMC1-promoted homologous pairing. May inhibit HIV-1 viral protein TAT activity and modulate the activity of proteasomes through association with PSMC3.<ref>PMID:9345291</ref> <ref>PMID:15192114</ref> <ref>PMID:16675459</ref> <ref>PMID:17639080</ref> <ref>PMID:17639081</ref> <ref>PMID:17426123</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Camerini-Otero | [[Category: Camerini-Otero RD]] | ||
[[Category: Eyter | [[Category: Eyter CA]] | ||
[[Category: Guiraldelli | [[Category: Guiraldelli MF]] | ||
[[Category: Moktan | [[Category: Moktan H]] | ||
[[Category: Pezza | [[Category: Pezza RJ]] | ||
[[Category: Sung | [[Category: Sung P]] | ||
[[Category: Zhao | [[Category: Zhao W]] | ||
[[Category: Zhou | [[Category: Zhou DH]] | ||
