1eig: Difference between revisions

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[[Image:1eig.jpg|left|200px]]
{{Seed}}
[[Image:1eig.png|left|200px]]


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{{STRUCTURE_1eig|  PDB=1eig  |  SCENE=  }}  
{{STRUCTURE_1eig|  PDB=1eig  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE EOTAXIN-2'''
===SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE EOTAXIN-2===




==Overview==
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The human CC chemokine eotaxin-2 is a specific agonist for the chemokine receptor CCR3 and may play a role in the recruitment of eosinophils in allergic diseases and parasitic infections. We report the solution structure of eotaxin-2 determined using heteronuclear and triple resonance NMR methods. A family of 20 structures was calculated by hybrid distance geometry-simulated annealing from 854 NOE distance restraints, 48 dihedral angle restraints, and 12 hydrogen bond restraints. The structure of eotaxin-2 (73 amino acid residues) consists of a helical turn (residues 17-20) followed by a 3-stranded antiparallel beta-sheet (residues 22-26, 37-41, and 44-49) and an alpha-helix (residues 54-66). The N-loop (residues 9-16) is packed against both the sheet and the helix with the two conserved disulfide bonds tethering the N-terminal/N-loop region to the beta-sheet. The average backbone and heavy atom rmsd values of the 20 structures (residues 7-66) are 0.52 and 1.13 A, respectively. A linear peptide corresponding to the N-terminal region of CCR3 binds to eotaxin-2, inducing concentration-dependent chemical shift changes or line broadening of many residues. The distribution of these residues suggests that the peptide binds into an extended groove located at the interface between the N-loop and the beta2-beta3 hairpin. The receptor peptide may also interact with the N-terminus of the chemokine and part of the alpha-helix. Comparison of the eotaxin-2 structure with those of related chemokines indicates several structural features that may contribute to receptor specificity.
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{{ABSTRACT_PUBMED_10913244}}


==About this Structure==
==About this Structure==
1EIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EIG OCA].  
1EIG is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EIG OCA].  


==Reference==
==Reference==
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[[Category: Chemotactic cytokine]]
[[Category: Chemotactic cytokine]]
[[Category: Eosinophil chemoattractant]]
[[Category: Eosinophil chemoattractant]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:08:26 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:45:33 2008''

Revision as of 21:45, 30 June 2008

File:1eig.png

Template:STRUCTURE 1eig

SOLUTION STRUCTURE OF THE HUMAN CHEMOKINE EOTAXIN-2

Template:ABSTRACT PUBMED 10913244

About this Structure

1EIG is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

NMR solution structure and receptor peptide binding of the CC chemokine eotaxin-2., Mayer KL, Stone MJ, Biochemistry. 2000 Jul 25;39(29):8382-95. PMID:10913244

Page seeded by OCA on Tue Jul 1 00:45:33 2008

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