1ej1: Difference between revisions

Line 1:

[[Image:1ej1.~~jpg~~|left|200px]]

[[Image:1ej1.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP~~'''~~

===COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP===

~~==Overview==~~

<!--

The ~~X-ray structure of~~ the ~~eukaryotic translation initiation factor 4E~~ (~~eIF4E), bound to 7-methyl-GDP, has been determined~~ at 2.~~2 A resolution~~. ~~eIF4E recognizes 5' 7-methyl-G(5')ppp(5'~~)N mRNA caps during the rate-limiting initiation step of translation. The protein resembles a cupped hand and consists of a curved, 8-stranded antiparallel beta sheet, backed by three long alpha helices. 7-methyl-GDP binds in a narrow cap-binding slot on the molecule's concave surface, where ~~7-methyl-guanine recognition~~ is mediated by base sandwiching between two conserved tryptophans, plus formation of three hydrogen bonds and a van der Waals contact between its N7-methyl group and a third conserved tryptophan. The convex dorsal surface of the ~~molecule displays a phylogenetically conserved hydrophobic/acidic portion, which may interact with other translation initiation factors and regulatory proteins~~.

The line below this paragraph, {{ABSTRACT_PUBMED_9200613}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 9200613 is the PubMed ID number.

-->

==About this Structure==

Line 27:

Line 31:

[[Category: Sonenberg, N.]]

[[Category: Protein 5' mrna cap complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 15~~:09:35 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:49:18 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1ej1.jpg|left|200px]]
+{{Seed}}
+[[Image:1ej1.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ej1|  PDB=1ej1  |  SCENE=  }}
-'''COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP'''
+===COCRYSTAL STRUCTURE OF THE MESSENGER RNA 5' CAP-BINDING PROTEIN (EIF4E) BOUND TO 7-METHYL-GDP===
-==Overview==
+<!--
-The X-ray structure of the eukaryotic translation initiation factor 4E (eIF4E), bound to 7-methyl-GDP, has been determined at 2.2 A resolution. eIF4E recognizes 5' 7-methyl-G(5')ppp(5')N mRNA caps during the rate-limiting initiation step of translation. The protein resembles a cupped hand and consists of a curved, 8-stranded antiparallel beta sheet, backed by three long alpha helices. 7-methyl-GDP binds in a narrow cap-binding slot on the molecule's concave surface, where 7-methyl-guanine recognition is mediated by base sandwiching between two conserved tryptophans, plus formation of three hydrogen bonds and a van der Waals contact between its N7-methyl group and a third conserved tryptophan. The convex dorsal surface of the molecule displays a phylogenetically conserved hydrophobic/acidic portion, which may interact with other translation initiation factors and regulatory proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_9200613}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 9200613 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_9200613}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Sonenberg, N.]]
 [[Category: Protein 5' mrna cap complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:09:35 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:49:18 2008''