1ej4: Difference between revisions

Line 1:

[[Image:1ej4.~~jpg~~|left|200px]]

[[Image:1ej4.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE~~'''~~

===COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE===

~~==Overview==~~

<!--

~~eIF4G uses a conserved Tyr~~-X-X-X-X-Leu-phi segment (where X is variable and phi is hydrophobic) to recognize eIF4E during cap-dependent translation initiation in eukaryotes. High-resolution X-ray crystallography and complementary biophysical methods have revealed that this ~~eIF4E recognition motif undergoes a disorder-to-order transition~~, ~~adopting an L-shaped~~, ~~extended chain~~/~~alpha-helical conformation when it interacts with a phylogenetically invariant portion of the convex surface of eIF4E~~. ~~Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs~~) ~~contain similar eIF4E recognition motifs. These molecules are molecular mimics of eIF4G~~, ~~which act by occupying the same binding site on~~ the ~~convex dorsum of eIF4E and blocking assembly of the translation machinery~~. ~~The implications of our results for translation initiation are discussed in detail, and a molecular mechanism for relief of translation inhibition following phosphorylation of the 4E~~-~~BPs is proposed.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10394359}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10394359 is the PubMed ID number.

-->

==About this Structure==

Line 27:

Line 31:

[[Category: Sonenberg, N.]]

[[Category: Eif4e/4e-bp/7-methyl-gdp]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 15~~:09:50 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:49:32 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1ej4.jpg|left|200px]]
+{{Seed}}
+[[Image:1ej4.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1ej4|  PDB=1ej4  |  SCENE=  }}
-'''COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE'''
+===COCRYSTAL STRUCTURE OF EIF4E/4E-BP1 PEPTIDE===
-==Overview==
+<!--
-eIF4G uses a conserved Tyr-X-X-X-X-Leu-phi segment (where X is variable and phi is hydrophobic) to recognize eIF4E during cap-dependent translation initiation in eukaryotes. High-resolution X-ray crystallography and complementary biophysical methods have revealed that this eIF4E recognition motif undergoes a disorder-to-order transition, adopting an L-shaped, extended chain/alpha-helical conformation when it interacts with a phylogenetically invariant portion of the convex surface of eIF4E. Inhibitors of translation initiation known as eIF4E-binding proteins (4E-BPs) contain similar eIF4E recognition motifs. These molecules are molecular mimics of eIF4G, which act by occupying the same binding site on the convex dorsum of eIF4E and blocking assembly of the translation machinery. The implications of our results for translation initiation are discussed in detail, and a molecular mechanism for relief of translation inhibition following phosphorylation of the 4E-BPs is proposed.
+The line below this paragraph, {{ABSTRACT_PUBMED_10394359}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10394359 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10394359}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Sonenberg, N.]]
 [[Category: Eif4e/4e-bp/7-methyl-gdp]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:09:50 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 00:49:32 2008''