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| <StructureSection load='6zm0' size='340' side='right'caption='[[6zm0]], [[Resolution|resolution]] 1.47Å' scene=''> | | <StructureSection load='6zm0' size='340' side='right'caption='[[6zm0]], [[Resolution|resolution]] 1.47Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[6zm0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZM0 FirstGlance]. <br> | | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZM0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZM0 FirstGlance]. <br> |
| </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.471Å</td></tr> |
| <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mreC, PA4480 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr> | | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> |
| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zm0 OCA], [https://pdbe.org/6zm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zm0 RCSB], [https://www.ebi.ac.uk/pdbsum/6zm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zm0 ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zm0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zm0 OCA], [https://pdbe.org/6zm0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zm0 RCSB], [https://www.ebi.ac.uk/pdbsum/6zm0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zm0 ProSAT]</span></td></tr> |
| </table> | | </table> |
| == Function ==
| |
| [[https://www.uniprot.org/uniprot/Q9HVU1_PSEAE Q9HVU1_PSEAE]] Involved in formation and maintenance of cell shape.[PIRNR:PIRNR038471]
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| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
| |
| The elongasome, or Rod system, is a protein complex that controls cell wall formation in rod-shaped bacteria. MreC is a membrane-associated elongasome component that co-localizes with the cytoskeletal element MreB and regulates the activity of cell wall biosynthesis enzymes, in a process that may be dependent on MreC self-association. Here, we use electron cryo-microscopy and X-ray crystallography to determine the structure of a self-associated form of MreC from Pseudomonas aeruginosa in atomic detail. MreC monomers interact in head-to-tail fashion. Longitudinal and lateral interfaces are essential for oligomerization in vitro, and a phylogenetic analysis of proteobacterial MreC sequences indicates the prevalence of the identified interfaces. Our results are consistent with a model where MreC's ability to alternate between self-association and interaction with the cell wall biosynthesis machinery plays a key role in the regulation of elongasome activity.
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| Self-association of MreC as a regulatory signal in bacterial cell wall elongation.,Martins A, Contreras-Martel C, Janet-Maitre M, Miyachiro MM, Estrozi LF, Trindade DM, Malospirito CC, Rodrigues-Costa F, Imbert L, Job V, Schoehn G, Attree I, Dessen A Nat Commun. 2021 May 20;12(1):2987. doi: 10.1038/s41467-021-22957-9. PMID:34016967<ref>PMID:34016967</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 6zm0" style="background-color:#fffaf0;"></div>
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| == References ==
| |
| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Pseae]]
| | [[Category: Contreras-Martel C]] |
| [[Category: Contreras-Martel, C]] | | [[Category: Dessen A]] |
| [[Category: Dessen, A]] | | [[Category: Trindade DM]] |
| [[Category: Trindade, D M]] | |
| [[Category: Cytoskeletal]]
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| [[Category: Elongasome]]
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| [[Category: Peptidoglycan]]
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| [[Category: Rod-shape bacteria]]
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| [[Category: Structural protein]]
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