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==NMR structure of the complex between the C-terminal domain of the Rift Valley fever virus protein NSs and the PH domain of the Tfb1 subunit of TFIIH==
==NMR structure of the complex between the C-terminal domain of the Rift Valley fever virus protein NSs and the PH domain of the Tfb1 subunit of TFIIH==
<StructureSection load='2n0y' size='340' side='right'caption='[[2n0y]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2n0y' size='340' side='right'caption='[[2n0y]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2n0y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast] and [https://en.wikipedia.org/wiki/Rvfv Rvfv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N0Y FirstGlance]. <br>
<table><tr><td colspan='2'>[[2n0y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rift_valley_fever_virus_(STRAIN_ZH-548_M12) Rift valley fever virus (STRAIN ZH-548 M12)] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N0Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N0Y FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2m14|2m14]], [[2lox|2lox]], [[1y5o|1y5o]]</div></td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n0y OCA], [https://pdbe.org/2n0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n0y RCSB], [https://www.ebi.ac.uk/pdbsum/2n0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n0y ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">D9740.3, TFB1, YDR311W ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), NSS ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11589 RVFV])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n0y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n0y OCA], [https://pdbe.org/2n0y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n0y RCSB], [https://www.ebi.ac.uk/pdbsum/2n0y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n0y ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST]] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref> [[https://www.uniprot.org/uniprot/NSS_RVFVZ NSS_RVFVZ]] Inhibits host general transcription by inhibiting host basal transcription factor TFIIH.<ref>PMID:21543505</ref> 
[https://www.uniprot.org/uniprot/TFB1_YEAST TFB1_YEAST] Acts as component of the general transcription and DNA repair factor IIH (TFIIH) core, which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH has CTD kinase and DNA-dependent ATPase activity, and is essential for polymerase II transcription in vitro.<ref>PMID:7961739</ref> <ref>PMID:8631896</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Rvfv]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Chabot, P R]]
[[Category: Chabot PR]]
[[Category: Cyr, N]]
[[Category: Cyr N]]
[[Category: Fuente, C de la]]
[[Category: Guendel I]]
[[Category: Guendel, I]]
[[Category: Kehn-Hall K]]
[[Category: Kehn-Hall, K]]
[[Category: Lecoq L]]
[[Category: Lecoq, L]]
[[Category: Omichinski JG]]
[[Category: Omichinski, J G]]
[[Category: De la Fuente C]]
[[Category: Drug target]]
[[Category: Transcription]]
[[Category: Transcription-viral protein complex]]
[[Category: Viral protein-transcription complex]]
[[Category: Virulence]]
[[Category: Virus-host interface]]
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