6xcz: Difference between revisions
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==Porcine pepsin in complex with saquinavir== | ==Porcine pepsin in complex with saquinavir== | ||
<StructureSection load='6xcz' size='340' side='right'caption='[[6xcz]]' scene=''> | <StructureSection load='6xcz' size='340' side='right'caption='[[6xcz]], [[Resolution|resolution]] 1.89Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XCZ FirstGlance]. <br> | <table><tr><td colspan='2'>[[6xcz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XCZ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcz OCA], [https://pdbe.org/6xcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcz RCSB], [https://www.ebi.ac.uk/pdbsum/6xcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcz ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ROC:(2S)-N-[(2S,3R)-4-[(2S,3S,4AS,8AS)-3-(TERT-BUTYLCARBAMOYL)-3,4,4A,5,6,7,8,8A-OCTAHYDRO-1H-ISOQUINOLIN-2-YL]-3-HYDROXY-1-PHENYL-BUTAN-2-YL]-2-(QUINOLIN-2-YLCARBONYLAMINO)BUTANEDIAMIDE'>ROC</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pepsin_A Pepsin A], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.1 3.4.23.1] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xcz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcz OCA], [https://pdbe.org/6xcz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcz RCSB], [https://www.ebi.ac.uk/pdbsum/6xcz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcz ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[[https://www.uniprot.org/uniprot/PEPA_PIG PEPA_PIG]] Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Silvaggi | [[Category: Pepsin A]] | ||
[[Category: Vuksanovic N]] | [[Category: Sus scrofa]] | ||
[[Category: Silvaggi, N R]] | |||
[[Category: Vuksanovic, N]] | |||
[[Category: Hiv]] | |||
[[Category: Hydrolase]] | |||
[[Category: Hydrolase-inhibitor complex]] | |||
[[Category: Inhibitor]] | |||
[[Category: Pepsin]] | |||
[[Category: Protease]] | |||
