1emz: Difference between revisions

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[[Image:1emz.gif|left|200px]]
{{Seed}}
[[Image:1emz.png|left|200px]]


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{{STRUCTURE_1emz|  PDB=1emz  |  SCENE=  }}  
{{STRUCTURE_1emz|  PDB=1emz  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1'''
===SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1===




==Overview==
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Oligomerization of viral envelope proteins is essential to control virus assembly and fusion. The transmembrane domains (TMDs) of hepatitis C virus envelope glycoproteins E1 and E2 have been shown to play multiple functions during the biogenesis of E1E2 heterodimer. This makes them very unique among known transmembrane sequences. In this report, we used alanine scanning insertion mutagenesis in the TMDs of E1 and E2 to examine their role in the assembly of E1E2 heterodimer. Alanine insertion within the center of the TMDs of E1 or E2 or in the N-terminal part of the TMD of E1 dramatically reduced heterodimerization, demonstrating the essential role played by these domains in the assembly of hepatitis C virus envelope glycoproteins. To better understand the alanine scanning data obtained for the TMD of E1 which contains GXXXG motifs, we analyzed by circular dichroism and nuclear magnetic resonance the three-dimensional structure of the E1-(350-370) peptide encompassing the N-terminal sequence of the TMD of E1 involved in heterodimerization. Alanine scanning results and the three-dimensional molecular model we obtained provide the first framework for a molecular level understanding of the mechanism of hepatitis C virus envelope glycoprotein heterodimerization.
The line below this paragraph, {{ABSTRACT_PUBMED_10807921}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10807921}}


==About this Structure==
==About this Structure==
1EMZ is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA].  
1EMZ is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1EMZ OCA].  


==Reference==
==Reference==
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[[Category: Peptide]]
[[Category: Peptide]]
[[Category: Transmembrane domain]]
[[Category: Transmembrane domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:17:55 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:00:38 2008''

Revision as of 22:00, 30 June 2008

File:1emz.png

Template:STRUCTURE 1emz

SOLUTION STRUCTURE OF FRAGMENT (350-370) OF THE TRANSMEMBRANE DOMAIN OF HEPATITIS C ENVELOPE GLYCOPROTEIN E1

Template:ABSTRACT PUBMED 10807921

About this Structure

1EMZ is a Single protein structure. Full experimental information is available from OCA.

Reference

The transmembrane domains of hepatitis C virus envelope glycoproteins E1 and E2 play a major role in heterodimerization., Op De Beeck A, Montserret R, Duvet S, Cocquerel L, Cacan R, Barberot B, Le Maire M, Penin F, Dubuisson J, J Biol Chem. 2000 Oct 6;275(40):31428-37. PMID:10807921

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