6w3k: Difference between revisions
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<StructureSection load='6w3k' size='340' side='right'caption='[[6w3k]], [[Resolution|resolution]] 2.08Å' scene=''> | <StructureSection load='6w3k' size='340' side='right'caption='[[6w3k]], [[Resolution|resolution]] 2.08Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6w3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[6w3k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6W3K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6W3K FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SJS:4-[5-[2,6-bis(fluoranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-oxidanylpiperidin-1-yl)-1~{H}-pyrimidin-6-one'>SJS</scene> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.08Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SJS:4-[5-[2,6-bis(fluoranyl)phenyl]-2~{H}-pyrazolo[3,4-b]pyridin-3-yl]-2-(4-oxidanylpiperidin-1-yl)-1~{H}-pyrimidin-6-one'>SJS</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w3k OCA], [https://pdbe.org/6w3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w3k RCSB], [https://www.ebi.ac.uk/pdbsum/6w3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w3k ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6w3k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6w3k OCA], [https://pdbe.org/6w3k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6w3k RCSB], [https://www.ebi.ac.uk/pdbsum/6w3k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6w3k ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ERN1_HUMAN ERN1_HUMAN] Senses unfolded proteins in the lumen of the endoplasmic reticulum via its N-terminal domain which leads to enzyme auto-activation. The active endoribonuclease domain splices XBP1 mRNA to generate a new C-terminus, converting it into a potent unfolded-protein response transcriptional activator and triggering growth arrest and apoptosis.<ref>PMID:9637683</ref> <ref>PMID:11175748</ref> <ref>PMID:12637535</ref> [UniProtKB:Q9EQY0] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6w3k" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6w3k" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Ire1|Ire1]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ferri | [[Category: Ferri E]] | ||
[[Category: Lammens | [[Category: Lammens A]] | ||
[[Category: Rudolph | [[Category: Rudolph J]] | ||
[[Category: Wang | [[Category: Wang W]] | ||
