1eo6: Difference between revisions

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[[Image:1eo6.gif|left|200px]]
{{Seed}}
[[Image:1eo6.png|left|200px]]


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{{STRUCTURE_1eo6|  PDB=1eo6  |  SCENE=  }}  
{{STRUCTURE_1eo6|  PDB=1eo6  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF GATE-16'''
===CRYSTAL STRUCTURE OF GATE-16===




==Overview==
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The GATE-16 protein participates in intra-Golgi transport and can associate with the N-ethylmaleimide-sensitive fusion protein and with Golgi SNAREs. The yeast ortholog of GATE-16 is the autophagocytosis factor Aut7p. GATE-16 is also closely related to the GABA receptor-associated protein (GABARAP), which has been proposed to cluster neurotransmitter receptors by mediating interaction with the cytoskeleton, and to the light chain-3 subunit of the neuronal microtubule-associated protein complex. Here, we present the crystal structure of GATE-16 refined to 1.8 A resolution. GATE-16 contains a ubiquitin fold decorated by two additional N-terminal helices. Proteins with strong structural similarity but no detectable sequence homology to GATE-16 include Ras effectors that mediate diverse downstream functions, but each interacts with Ras by forming pseudo-continuous beta-sheets. The GATE-16 surface suggests that it binds its targets in a similar manner. Moreover, a second potential protein-protein interaction site on GATE-16 may explain the adapter activity observed for members of the GATE-16 family.
The line below this paragraph, {{ABSTRACT_PUBMED_10856287}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10856287 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10856287}}


==About this Structure==
==About this Structure==
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[[Category: Paz, Y.]]
[[Category: Paz, Y.]]
[[Category: Ubiquitin fold]]
[[Category: Ubiquitin fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:20:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 01:15:41 2008''

Revision as of 22:15, 30 June 2008

File:1eo6.png

Template:STRUCTURE 1eo6

CRYSTAL STRUCTURE OF GATE-16

Template:ABSTRACT PUBMED 10856287

About this Structure

1EO6 is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structure of GATE-16, membrane transport modulator and mammalian ortholog of autophagocytosis factor Aut7p., Paz Y, Elazar Z, Fass D, J Biol Chem. 2000 Aug 18;275(33):25445-50. PMID:10856287

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