7azw: Difference between revisions
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==Crystal structure of the MIZ1-BTB-domain== | ==Crystal structure of the MIZ1-BTB-domain== | ||
<StructureSection load='7azw' size='340' side='right'caption='[[7azw]]' scene=''> | <StructureSection load='7azw' size='340' side='right'caption='[[7azw]], [[Resolution|resolution]] 2.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AZW FirstGlance]. <br> | <table><tr><td colspan='2'>[[7azw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AZW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AZW FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7azw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7azw OCA], [https://pdbe.org/7azw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7azw RCSB], [https://www.ebi.ac.uk/pdbsum/7azw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7azw ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7azw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7azw OCA], [https://pdbe.org/7azw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7azw RCSB], [https://www.ebi.ac.uk/pdbsum/7azw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7azw ProSAT]</span></td></tr> | |||
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
The repurposing of structurally conserved protein domains in different functional contexts is thought to be a driving force in the evolution of complex protein interaction networks. The BTB/POZ domain is such a versatile binding module that occurs over 200 times in the human proteome with diverse protein-specific adaptations. In BTB-zinc-finger transcription factors, the BTB domain drives homo- and heterodimerization as well as interactions with non-BTB-domain-containing proteins. Which mechanisms encode specificity in these interactions at a structural level is incompletely understood. Here, we uncover an atypical peptide-binding site in the BTB domain of the MYC-interacting zinc-finger protein 1 (MIZ1) that arises from local flexibility of the core BTB fold and may provide a target site for MIZ1-directed therapeutic approaches. Intriguingly, the identified binding mode requires the BTB domain to be in a homodimeric state, thus holding opportunities for functional discrimination between homo- and heterodimers of MIZ1 in the cell. | |||
Identification of an atypical interaction site in the BTB domain of the MYC-interacting zinc-finger protein 1.,Orth B, Sander B, Moglich A, Diederichs K, Eilers M, Lorenz S Structure. 2021 Jun 22. pii: S0969-2126(21)00209-4. doi:, 10.1016/j.str.2021.06.005. PMID:34186024<ref>PMID:34186024</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7azw" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Diederichs K]] | [[Category: Diederichs, K]] | ||
[[Category: Lorenz S]] | [[Category: Lorenz, S]] | ||
[[Category: Orth B]] | [[Category: Orth, B]] | ||
[[Category: Sander B]] | [[Category: Sander, B]] | ||
[[Category: Btb-domain]] | |||
[[Category: Dimer]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription factor]] | |||
