7jkx: Difference between revisions
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==Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with YF3-6== | ==Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with YF3-6== | ||
<StructureSection load='7jkx' size='340' side='right'caption='[[7jkx]]' scene=''> | <StructureSection load='7jkx' size='340' side='right'caption='[[7jkx]], [[Resolution|resolution]] 1.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JKX FirstGlance]. <br> | <table><tr><td colspan='2'>[[7jkx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JKX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JKX FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jkx OCA], [https://pdbe.org/7jkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jkx RCSB], [https://www.ebi.ac.uk/pdbsum/7jkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jkx ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=Y36:N-{1-[1,1-di(pyridin-2-yl)ethyl]-6-[1-methyl-5-(methylamino)-6-oxo-1,6-dihydropyridin-3-yl]-1H-indol-4-yl}ethanesulfonamide'>Y36</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BRD4, HUNK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jkx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jkx OCA], [https://pdbe.org/7jkx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jkx RCSB], [https://www.ebi.ac.uk/pdbsum/7jkx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jkx ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN]] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Dubrovyskyii O]] | [[Category: Dubrovyskyii, O]] | ||
[[Category: Huang F]] | [[Category: Huang, F]] | ||
[[Category: Li Y]] | [[Category: Li, Y]] | ||
[[Category: Ratia | [[Category: Ratia, K M]] | ||
[[Category: Shen Z]] | [[Category: Shen, Z]] | ||
[[Category: Thatcher | [[Category: Thatcher, G R]] | ||
[[Category: Xiong R]] | [[Category: Xiong, R]] | ||
[[Category: Zhao J]] | [[Category: Zhao, J]] | ||
[[Category: Pan bds inhibitor]] | |||
[[Category: Structural genomic]] | |||
[[Category: Ssgcid]] | |||
[[Category: Transcription]] | |||
Revision as of 09:04, 8 September 2021
Bromodomain-containing protein 4 (BRD4) bromodomain 1 (BD1) complexed with YF3-6
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