2qos: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
Line 3: Line 3:
<StructureSection load='2qos' size='340' side='right'caption='[[2qos]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
<StructureSection load='2qos' size='340' side='right'caption='[[2qos]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QOS FirstGlance]. <br>
<table><tr><td colspan='2'>[[2qos]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QOS FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1lf7|1lf7]], [[1iw2|1iw2]], [[2ove|2ove]], [[2ova|2ova]], [[2ovd|2ovd]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.81&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">C8G ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [https://pdbe.org/2qos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [https://www.ebi.ac.uk/pdbsum/2qos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qos ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qos OCA], [https://pdbe.org/2qos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qos RCSB], [https://www.ebi.ac.uk/pdbsum/2qos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qos ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Defects in C8A are a cause of complement component 8 deficiency type 1 (C8D1) [MIM:[https://omim.org/entry/613790 613790]]. A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN]] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol. [[https://www.uniprot.org/uniprot/CO8A_HUMAN CO8A_HUMAN]] Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself.<ref>PMID:7440581</ref> <ref>PMID:17872444</ref> 
[https://www.uniprot.org/uniprot/CO8G_HUMAN CO8G_HUMAN] C8 is a constituent of the membrane attack complex. C8 binds to the C5B-7 complex, forming the C5B-8 complex. C5-B8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 35: Line 32:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chiswell, B]]
[[Category: Chiswell B]]
[[Category: Lebioda, L]]
[[Category: Lebioda L]]
[[Category: Lovelace, L L]]
[[Category: Lovelace LL]]
[[Category: Slade, D J]]
[[Category: Slade DJ]]
[[Category: Sodetz, J M]]
[[Category: Sodetz JM]]
[[Category: Beta barrel]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Complement alternate pathway]]
[[Category: Complement pathway]]
[[Category: Cytolysis]]
[[Category: Egf-like domain]]
[[Category: Glycoprotein]]
[[Category: Immune response]]
[[Category: Immune system]]
[[Category: Innate immunity]]
[[Category: Lipocalin]]
[[Category: Membrane attack complex]]
[[Category: Polymorphism]]
[[Category: Secreted]]
Retrieved from "https://proteopedia.org/2qos"