Protein crosslinks: Difference between revisions
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==Natural Crosslinks== | ==Natural Crosslinks== | ||
*[[Disulfide bonds]] are the most common protein crosslinks. About 23% of protein structures in the [[PDB]] have disulfide bonds (July, 2021). Example: Insulin [[9ins]] has 2 interchain and one intrachain disulfide bonds. | *<big>[[Disulfide bonds]]</big> are the most common protein crosslinks. About 23% of protein structures in the [[PDB]] have disulfide bonds | ||
(July, 2021<ref>In July, 2021, the PDB had ~180,000 entries. Advanced search for "Polymer molecuar features: polymer entity type = protein" and "Deposited entry features: Disulfide bond count per deposited model > 0" gave ~41,000 hits, or about 23%.</ref>). | |||
Example: Insulin [[9ins]] has 2 interchain and one intrachain disulfide bonds. | |||
**Visualization: [https://firstglance.jmol.org/fg.htm?mol=9ins View 9ins in FirstGlance]. In [[FirstGlance]], in the Tools tab, click Disulfides/S/Se. | **Visualization: [https://firstglance.jmol.org/fg.htm?mol=9ins View 9ins in FirstGlance]. In [[FirstGlance]], in the Tools tab, click Disulfides/S/Se. | ||
*[[Isopeptide bonds]] | *<big>[[Isopeptide bonds]]</big> are less common, but an estimate of their frequency may not be available. A text search for "isopeptide" at RCSB.Org gives 433 hits, while a search at PDBe gives >11,000 hits. In a small sample of the latter hits, none contained the term "isopeptide". Also based on a small sample, some entries that contain verified isopeptide bonds do not contain the term. | ||
**Visualization: [https://firstglance.jmol.org/fg.htm?mol=9ins View 9ins in FirstGlance]. In [[FirstGlance]], in the Tools tab, click Disulfides/S/Se. | |||
==Notes== | |||
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