1bbs: Difference between revisions
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New page: left|200px<br /> <applet load="1bbs" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bbs, resolution 2.8Å" /> '''X-RAY ANALYSES OF PE... |
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[[Image:1bbs.gif|left|200px]]<br /> | [[Image:1bbs.gif|left|200px]]<br /><applet load="1bbs" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1bbs" size=" | |||
caption="1bbs, resolution 2.8Å" /> | caption="1bbs, resolution 2.8Å" /> | ||
'''X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS'''<br /> | '''X-RAY ANALYSES OF PEPTIDE INHIBITOR COMPLEXES DEFINE THE STRUCTURAL BASIS OF SPECIFICITY FOR HUMAN AND MOUSE RENINS'''<br /> | ||
==Overview== | ==Overview== | ||
X-ray analyses have defined the three-dimensional structures of crystals | X-ray analyses have defined the three-dimensional structures of crystals of mouse and human renins complexed with peptide inhibitors at resolutions of 1.9 and 2.8 A, respectively. The exquisite specificity of renin arises partly from ordered loop regions at the periphery of the binding cleft. Although the pattern of main-chain hydrogen bonding in other aspartic proteinase inhibitor complexes is conserved in renins, differences in the positions of secondary structure elements (particularly helices) also lead to improved specificity in renins for angiotensinogen substrates. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1BBS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Full crystallographic information is available from [http:// | 1BBS is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Active as [http://en.wikipedia.org/wiki/Renin Renin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.15 3.4.23.15] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BBS OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Renin]] | [[Category: Renin]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Blundell, T | [[Category: Blundell, T L.]] | ||
[[Category: Dhanaraj, V.]] | [[Category: Dhanaraj, V.]] | ||
[[Category: aspartic proteinase]] | [[Category: aspartic proteinase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:53:35 2008'' | ||
