2vaq: Difference between revisions

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<StructureSection load='2vaq' size='340' side='right'caption='[[2vaq]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
<StructureSection load='2vaq' size='340' side='right'caption='[[2vaq]], [[Resolution|resolution]] 3.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2vaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Ophioxylon_serpentinum Ophioxylon serpentinum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2vaq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rauvolfia_serpentina Rauvolfia serpentina]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VAW:(2S,3R,4S)-METHYL+4-(2-(2-(1H-INDOL-3-YL)ETHYLAMINO)ETHYL)-2-((2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YLOXY)-3-VINYL-3,4-DIHYDRO-2H-PYRAN-5-CARBOXYLATE'>VAW</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.01&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2fp8|2fp8]], [[2fp9|2fp9]], [[2fpb|2fpb]], [[2v91|2v91]], [[2fpc|2fpc]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VAW:(2S,3R,4S)-METHYL+4-(2-(2-(1H-INDOL-3-YL)ETHYLAMINO)ETHYL)-2-((2S,3R,4S,5S,6R)-3,4,5-TRIHYDROXY-6-(HYDROXYMETHYL)TETRAHYDRO-2H-PYRAN-2-YLOXY)-3-VINYL-3,4-DIHYDRO-2H-PYRAN-5-CARBOXYLATE'>VAW</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Strictosidine_synthase Strictosidine synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.3.3.2 4.3.3.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vaq OCA], [https://pdbe.org/2vaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vaq RCSB], [https://www.ebi.ac.uk/pdbsum/2vaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vaq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vaq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vaq OCA], [https://pdbe.org/2vaq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vaq RCSB], [https://www.ebi.ac.uk/pdbsum/2vaq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vaq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE]] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.  
[https://www.uniprot.org/uniprot/STSY_RAUSE STSY_RAUSE] Catalyzes the stereospecific condensation of tryptamine with secologanin to form strictosidine, the key intermediate of indole alkaloid biosynthesis.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ophioxylon serpentinum]]
[[Category: Rauvolfia serpentina]]
[[Category: Strictosidine synthase]]
[[Category: Friedrich A]]
[[Category: Connor, S E.O]]
[[Category: Giddings LA]]
[[Category: Friedrich, A]]
[[Category: Loris EA]]
[[Category: Giddings, L A]]
[[Category: Maresh J]]
[[Category: Loris, E A]]
[[Category: O'Connor SE]]
[[Category: Maresh, J]]
[[Category: Panjikar S]]
[[Category: Panjikar, S]]
[[Category: Peters B]]
[[Category: Peters, B]]
[[Category: Stoeckigt J]]
[[Category: Stoeckigt, J]]
[[Category: Trout BL]]
[[Category: Trout, B L]]
[[Category: Alkaloid metabolism]]
[[Category: Glycoprotein]]
[[Category: Lyase]]
[[Category: Six bladed beta propeller fold]]
[[Category: Str1]]
[[Category: Synthase]]
[[Category: Vacuole]]
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