2wmc: Difference between revisions

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<StructureSection load='2wmc' size='340' side='right'caption='[[2wmc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='2wmc' size='340' side='right'caption='[[2wmc]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wmc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Garden_pea Garden pea]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WMC FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wmc]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Pisum_sativum Pisum sativum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WMC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGP:7-METHYL-GUANOSINE-5-TRIPHOSPHATE'>MGP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MGP:7-METHYL-GUANOSINE-5-TRIPHOSPHATE'>MGP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmc OCA], [https://pdbe.org/2wmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wmc RCSB], [https://www.ebi.ac.uk/pdbsum/2wmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmc ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wmc OCA], [https://pdbe.org/2wmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wmc RCSB], [https://www.ebi.ac.uk/pdbsum/2wmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wmc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IF4E1_PEA IF4E1_PEA] Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome (PubMed:15469495, PubMed:21283665). Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures (PubMed:15469495, PubMed:21283665). Key component of recessive resistance to potyviruses (PubMed:15469495, PubMed:17849710, PubMed:21283665, PubMed:24609094).<ref>PMID:15469495</ref> <ref>PMID:17849710</ref> <ref>PMID:21283665</ref> <ref>PMID:24609094</ref>  (Microbial infection) Susceptibility host factor required for viral infection by recruiting viral RNAs to the host ribosomal complex via an interaction with viral genome-linked protein (VPg) (PubMed:15469495, PubMed:17849710, PubMed:24609094, PubMed:21283665). Seems also involved in virus movement from cell-to-cell (PubMed:15469495).<ref>PMID:15469495</ref> <ref>PMID:17849710</ref> <ref>PMID:21283665</ref> <ref>PMID:24609094</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Garden pea]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ashby, J A]]
[[Category: Lawson, D M]]
[[Category: Maule, A J]]
[[Category: Stevenson, C E.M]]
[[Category: Biosynthetic protein]]
[[Category: Eif4e]]
[[Category: Initiation factor]]
[[Category: Pisum sativum]]
[[Category: Pisum sativum]]
[[Category: Protein biosynthesis]]
[[Category: Ashby JA]]
[[Category: Rna-binding]]
[[Category: Lawson DM]]
[[Category: Sbm1 gene]]
[[Category: Maule AJ]]
[[Category: Stevenson CEM]]
Retrieved from "https://proteopedia.org/2wmc"