2woq: Difference between revisions

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<StructureSection load='2woq' size='340' side='right'caption='[[2woq]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='2woq' size='340' side='right'caption='[[2woq]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2woq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2woq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WOQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WOQ FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYC:ALAREMYCIN+2'>AYC</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2c18|2c18]], [[2c14|2c14]], [[1gzg|1gzg]], [[2c19|2c19]], [[1w5p|1w5p]], [[2c13|2c13]], [[1w5n|1w5n]], [[1w5q|1w5q]], [[1w54|1w54]], [[1w5m|1w5m]], [[1w5o|1w5o]], [[1w56|1w56]], [[2c16|2c16]], [[2c15|2c15]], [[1b4k|1b4k]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AYC:ALAREMYCIN+2'>AYC</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Porphobilinogen_synthase Porphobilinogen synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.24 4.2.1.24] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2woq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2woq OCA], [https://pdbe.org/2woq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2woq RCSB], [https://www.ebi.ac.uk/pdbsum/2woq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2woq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2woq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2woq OCA], [https://pdbe.org/2woq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2woq RCSB], [https://www.ebi.ac.uk/pdbsum/2woq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2woq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/HEM2_PSEAE HEM2_PSEAE]] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).  
[https://www.uniprot.org/uniprot/HEM2_PSEAE HEM2_PSEAE] Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Porphobilinogen synthase]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Awa, Y]]
[[Category: Awa Y]]
[[Category: Heinemann, I U]]
[[Category: Heinemann IU]]
[[Category: Heinz, D W]]
[[Category: Heinz DW]]
[[Category: Jahn, D]]
[[Category: Jahn D]]
[[Category: Jahn, M]]
[[Category: Jahn M]]
[[Category: Kobayashi, Y]]
[[Category: Kobayashi Y]]
[[Category: Schubert, W D]]
[[Category: Schubert W-D]]
[[Category: Schulz, C]]
[[Category: Schulz C]]
[[Category: Wachi, M]]
[[Category: Wachi M]]
[[Category: Wang, Y G]]
[[Category: Wang Y-G]]
[[Category: Hemb]]
[[Category: Heme biosynthesis]]
[[Category: Inhibitor]]
[[Category: Lyase]]
[[Category: Lyase antibiotic complex]]
[[Category: Lyase-antibiotic complex]]
[[Category: Metal-binding]]
[[Category: Porphyrin biosynthesis]]
[[Category: Porpobilinogen synthase]]
Retrieved from "https://proteopedia.org/2woq"