1euv: Difference between revisions

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[[Image:1euv.~~gif~~|left|200px]]

[[Image:1euv.png|left|200px]]

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~~'''~~X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.~~'''~~

===X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.===

~~==Overview==~~

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~~Modification of cellular proteins by the ubiquitin-like protein SUMO is essential for nuclear processes and cell cycle progression in yeast.~~ The ~~Ulp1 protease catalyzes two essential functions in~~ the ~~SUMO pathway: (1) processing of full-length SUMO~~ to ~~its mature form and~~ (2) deconjugation of SUMO from targeted proteins. Selective reduction of the proteolytic reaction produced a covalent thiohemiacetal transition state complex between a Ulp1 C-terminal fragment and its cellular substrate Smt3, the ~~yeast SUMO homolog~~. ~~The Ulp1~~-Smt3 crystal structure and functional testing of elements within the conserved interface elucidate determinants of SUMO recognition, processing, and deconjugation. Genetic analysis guided by the structure further reveals a regulatory element N-~~terminal to the proteolytic domain that is required for cell growth in yeast.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10882122}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10882122 is the PubMed ID number.

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==About this Structure==

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[[Category: Thiohemiacetal]]

[[Category: Ubiquitin-like protease 1]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 15~~:32:36 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:03:29 2008''

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-[[Image:1euv.gif|left|200px]]
+{{Seed}}
+[[Image:1euv.png|left|200px]]
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 {{STRUCTURE_1euv|  PDB=1euv  |  SCENE=  }}
-'''X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.'''
+===X-RAY STRUCTURE OF THE C-TERMINAL ULP1 PROTEASE DOMAIN IN COMPLEX WITH SMT3, THE YEAST ORTHOLOG OF SUMO.===
-==Overview==
+<!--
-Modification of cellular proteins by the ubiquitin-like protein SUMO is essential for nuclear processes and cell cycle progression in yeast. The Ulp1 protease catalyzes two essential functions in the SUMO pathway: (1) processing of full-length SUMO to its mature form and (2) deconjugation of SUMO from targeted proteins. Selective reduction of the proteolytic reaction produced a covalent thiohemiacetal transition state complex between a Ulp1 C-terminal fragment and its cellular substrate Smt3, the yeast SUMO homolog. The Ulp1-Smt3 crystal structure and functional testing of elements within the conserved interface elucidate determinants of SUMO recognition, processing, and deconjugation. Genetic analysis guided by the structure further reveals a regulatory element N-terminal to the proteolytic domain that is required for cell growth in yeast.
+The line below this paragraph, {{ABSTRACT_PUBMED_10882122}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10882122 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10882122}}
 ==About this Structure==
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 [[Category: Thiohemiacetal]]
 [[Category: Ubiquitin-like protease 1]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:32:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:03:29 2008''