7np5: Difference between revisions

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<StructureSection load='7np5' size='340' side='right'caption='[[7np5]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
<StructureSection load='7np5' size='340' side='right'caption='[[7np5]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7np5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NP5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7np5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7NP5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7NP5 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UKB:4-[[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-3-yl)-1,2-oxazol-4-yl]methoxy]-2-fluoranyl-benzoic+acid'>UKB</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">RORC, NR1F3, RORG, RZRG ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UKB:4-[[3-[2-chloranyl-6-(trifluoromethyl)phenyl]-5-(1~{H}-pyrrol-3-yl)-1,2-oxazol-4-yl]methoxy]-2-fluoranyl-benzoic+acid'>UKB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7np5 OCA], [https://pdbe.org/7np5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7np5 RCSB], [https://www.ebi.ac.uk/pdbsum/7np5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7np5 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7np5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7np5 OCA], [https://pdbe.org/7np5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7np5 RCSB], [https://www.ebi.ac.uk/pdbsum/7np5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7np5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.  
[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Brunsveld, L]]
[[Category: Brunsveld L]]
[[Category: Meijer, F A]]
[[Category: Meijer FA]]
[[Category: Oerlemans, G J.M]]
[[Category: Oerlemans GJM]]
[[Category: Somsen, B A]]
[[Category: Somsen BA]]
[[Category: Vries, R M.J M.de]]
[[Category: De Vries RMJM]]
[[Category: Inverse agonist]]
[[Category: Nuclear protein]]
[[Category: Nuclear receptor]]
[[Category: Retinoic acid receptor-related orphan receptor gamma t]]
Retrieved from "https://proteopedia.org/7np5"