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==Solution Structure of the Major Cherry Allergen Pru av 1==
==Solution Structure of the Major Cherry Allergen Pru av 1==
<StructureSection load='1e09' size='340' side='right'caption='[[1e09]], [[NMR_Ensembles_of_Models | 22 NMR models]]' scene=''>
<StructureSection load='1e09' size='340' side='right'caption='[[1e09]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1e09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Cerasus_avium Cerasus avium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E09 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1e09]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Prunus_avium Prunus avium]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E09 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1E09 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1btv|1btv]], [[1b6f|1b6f]], [[1bv1|1bv1]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e09 OCA], [https://pdbe.org/1e09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e09 RCSB], [https://www.ebi.ac.uk/pdbsum/1e09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e09 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1e09 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1e09 OCA], [https://pdbe.org/1e09 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1e09 RCSB], [https://www.ebi.ac.uk/pdbsum/1e09 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1e09 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRU1_PRUAV PRU1_PRUAV]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e09 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1e09 ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Birch pollinosis is often accompanied by hypersensitivity to fruit as a consequence of the cross-reaction of pollen allergen-specific IgE antibodies with homologous food proteins. To provide a basis for examining the cross-reactivity on a structural level, we used heteronuclear multidimensional NMR spectroscopy to determine the high-resolution three-dimensional structure of the major cherry allergen, Pru av 1, in solution. Based on a detailed comparison of the virtually identical structures of Pru av 1 and Bet v 1, the major birch pollen allergen, we propose an explanation for a significant aspect of the observed cross-reactivity pattern among the family of allergens under consideration. The large hydrophobic cavity expected to be important for the still unknown physiological function of Bet v 1 is conserved in Pru av 1. Structural homology to a domain of human MLN64 associated with cholesterol transport suggests phytosteroids as putative ligands for Pru av 1. NMR spectroscopy provides experimental evidence that Pru av 1 interacts with phytosteroids, and molecular modeling shows that the hydrophobic cavity is large enough to accommodate two such molecules.
Allergic cross-reactivity made visible: solution structure of the major cherry allergen Pru av 1.,Neudecker P, Schweimer K, Nerkamp J, Scheurer S, Vieths S, Sticht H, Rosch P J Biol Chem. 2001 Jun 22;276(25):22756-63. Epub 2001 Apr 3. PMID:11287426<ref>PMID:11287426</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1e09" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Cerasus avium]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Boehm, M]]
[[Category: Prunus avium]]
[[Category: Nerkamp, J]]
[[Category: Boehm M]]
[[Category: Neudecker, P]]
[[Category: Nerkamp J]]
[[Category: Roesch, P]]
[[Category: Neudecker P]]
[[Category: Scheurer, S]]
[[Category: Roesch P]]
[[Category: Schweimer, K]]
[[Category: Scheurer S]]
[[Category: Sticht, H]]
[[Category: Schweimer K]]
[[Category: Vieths, S]]
[[Category: Sticht H]]
[[Category: Allergen]]
[[Category: Vieths S]]
[[Category: Heteronuclear nmr]]
[[Category: Major cherry allergen]]
[[Category: Pathogenesis-related protein]]

Revision as of 09:56, 20 March 2024

Solution Structure of the Major Cherry Allergen Pru av 1

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