1exr: Difference between revisions

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[[Image:1exr.jpg|left|200px]]
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[[Image:1exr.png|left|200px]]


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{{STRUCTURE_1exr|  PDB=1exr  |  SCENE=  }}  
{{STRUCTURE_1exr|  PDB=1exr  |  SCENE=  }}  


'''THE 1.0 ANGSTROM CRYSTAL STRUCTURE OF CA+2 BOUND CALMODULIN'''
===THE 1.0 ANGSTROM CRYSTAL STRUCTURE OF CA+2 BOUND CALMODULIN===




==Overview==
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Calmodulin (CaM) is a highly conserved 17 kDa eukaryotic protein that can bind specifically to over 100 protein targets in response to a Ca(2+) signal. Ca(2+)-CaM requires a considerable degree of structural plasticity to accomplish this physiological role; however, the nature and extent of this plasticity remain poorly characterized. Here, we present the 1.0 A crystal structure of Paramecium tetraurelia Ca(2+)-CaM, including 36 discretely disordered residues and a fifth Ca(2+) that mediates a crystal contact. The 36 discretely disordered residues are located primarily in the central helix and the two hydrophobic binding pockets, and reveal correlated side-chain disorder that may assist target-specific deformation of the binding pockets. Evidence of domain displacements and discrete backbone disorder is provided by translation-libration-screw (TLS) analysis and multiconformer models of protein disorder, respectively. In total, the evidence for disorder at every accessible length-scale in Ca(2+)-CaM suggests that the protein occupies a large number of hierarchically arranged conformational substates in the crystalline environment and may sample a quasi-continuous spectrum of conformations in solution. Therefore, we propose that the functionally distinct forms of CaM are less structurally distinct than previously believed, and that the different activities of CaM in response to Ca(2+) may result primarily from Ca(2+)-mediated alterations in the dynamics of the protein.
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{{ABSTRACT_PUBMED_10966818}}


==About this Structure==
==About this Structure==
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[[Category: Disorder]]
[[Category: Disorder]]
[[Category: High resolution]]
[[Category: High resolution]]
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Revision as of 23:10, 30 June 2008

File:1exr.png

Template:STRUCTURE 1exr

THE 1.0 ANGSTROM CRYSTAL STRUCTURE OF CA+2 BOUND CALMODULIN

Template:ABSTRACT PUBMED 10966818

About this Structure

1EXR is a Single protein structure of sequence from Paramecium tetraurelia. Full crystallographic information is available from OCA.

Reference

The 1.0 A crystal structure of Ca(2+)-bound calmodulin: an analysis of disorder and implications for functionally relevant plasticity., Wilson MA, Brunger AT, J Mol Biol. 2000 Sep 1;301(5):1237-56. PMID:10966818

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