7kga: Difference between revisions

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<StructureSection load='7kga' size='340' side='right'caption='[[7kga]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='7kga' size='340' side='right'caption='[[7kga]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7kga]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KGA FirstGlance]. <br>
<table><tr><td colspan='2'>[[7kga]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Donggang_virus Donggang virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KGA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KGA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IRI:IRIDIUM+HEXAMMINE+ION'>IRI</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kga OCA], [https://pdbe.org/7kga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kga RCSB], [https://www.ebi.ac.uk/pdbsum/7kga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kga ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kga OCA], [https://pdbe.org/7kga PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kga RCSB], [https://www.ebi.ac.uk/pdbsum/7kga PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kga ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Mosquito-borne flaviviruses (MBFVs) including dengue, West Nile, yellow fever, and Zika viruses have an RNA genome encoding one open reading frame flanked by 5' and 3' untranslated regions (UTRs). The 3' UTRs of MBFVs contain regions of high sequence conservation in structured RNA elements known as dumbbells (DBs). DBs regulate translation and replication of the viral RNA genome, functions proposed to depend on the formation of an RNA pseudoknot. To understand how DB structure provides this function, we solved the x-ray crystal structure of the Donggang virus DB to 2.1A resolution and used structural modeling to reveal the details of its three-dimensional fold. The structure confirmed the predicted pseudoknot and molecular modeling revealed how conserved sequences form a four-way junction that appears to stabilize the pseudoknot. Single-molecule FRET suggests that the DB pseudoknot is a stable element that can regulate the switch between translation and replication during the viral lifecycle by modulating long-range RNA conformational changes.
Three-dimensional structure of a flavivirus dumbbell RNA reveals molecular details of an RNA regulator of replication.,Akiyama BM, Graham ME, O Donoghue Z, Beckham JD, Kieft JS Nucleic Acids Res. 2021 Jul 9;49(12):7122-7138. doi: 10.1093/nar/gkab462. PMID:34133732<ref>PMID:34133732</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7kga" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Donggang virus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Akiyama, B M]]
[[Category: Akiyama BM]]
[[Category: Beckham, J D]]
[[Category: Beckham JD]]
[[Category: Donoghue, Z O]]
[[Category: Graham ME]]
[[Category: Graham, M E]]
[[Category: Kieft JS]]
[[Category: Kieft, J S]]
[[Category: O'Donoghue Z]]
[[Category: Flavivirus]]
[[Category: Noncoding rna]]
[[Category: Rna]]
[[Category: Viral replication]]
[[Category: Viral rna]]
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