1f08: Difference between revisions

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[[Image:1f08.~~gif~~|left|200px]]

[[Image:1f08.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS~~'''~~

===CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS===

~~==Overview==~~

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~~Papillomaviral infection causes both benign and malignant lesions and is a necessary cause of cervical carcinoma. Replication of~~ this ~~virus requires~~ the ~~replication initiation proteins E1 and E2, which bind cooperatively at~~ the ~~origin of replication~~ (~~ori)~~ as an (E1)2-(E2)2-DNA complex. This is a precursor to larger E1 complexes that distort and unwind the ori. We present the crystal structure of the E1 DNA binding domain refined to 1.9 A resolution. Residues critical for DNA binding are located on ~~an extended loop and an alpha helix. We identify the E1 dimerization surface by selective mutations~~ at ~~an E1~~/~~E1 interface observed in the crystal and propose a model for the (E1~~)~~2-DNA complex. These and other observations suggest how~~ the ~~E1 DNA binding domain orchestrates assembly of the hexameric helicase on the ori~~.

The line below this paragraph, {{ABSTRACT_PUBMED_10949036}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10949036 is the PubMed ID number.

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==About this Structure==

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[[Category: Papillomavirus]]

[[Category: Replication]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 15~~:44:14 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:17:25 2008''

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-[[Image:1f08.gif|left|200px]]
+{{Seed}}
+[[Image:1f08.png|left|200px]]
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 {{STRUCTURE_1f08|  PDB=1f08  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS'''
+===CRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF THE REPLICATION INITIATION PROTEIN E1 FROM PAPILLOMAVIRUS===
-==Overview==
+<!--
-Papillomaviral infection causes both benign and malignant lesions and is a necessary cause of cervical carcinoma. Replication of this virus requires the replication initiation proteins E1 and E2, which bind cooperatively at the origin of replication (ori) as an (E1)2-(E2)2-DNA complex. This is a precursor to larger E1 complexes that distort and unwind the ori. We present the crystal structure of the E1 DNA binding domain refined to 1.9 A resolution. Residues critical for DNA binding are located on an extended loop and an alpha helix. We identify the E1 dimerization surface by selective mutations at an E1/E1 interface observed in the crystal and propose a model for the (E1)2-DNA complex. These and other observations suggest how the E1 DNA binding domain orchestrates assembly of the hexameric helicase on the ori.
+The line below this paragraph, {{ABSTRACT_PUBMED_10949036}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10949036 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10949036}}
 ==About this Structure==
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 [[Category: Papillomavirus]]
 [[Category: Replication]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 15:44:14 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:17:25 2008''