1bmp: Difference between revisions

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[[Image:1bmp.gif|left|200px]]<br />

[[Image:1bmp.gif|left|200px]]<br /><applet load="1bmp" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1bmp" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1bmp, resolution 2.8Å" />

'''BONE MORPHOGENETIC PROTEIN-7'''<br />

==Overview==

We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a, member of the transforming growth factor beta (TGF-beta) superfamily of, proteins and is able to induce new bone formation in vivo. Members of this, superfamily share sequence similarity in their C-terminal regions and are, implicated in embryonic development and adult tissue repair. Our crystal, structure makes possible the structural comparison between two members of, the TGF-beta superfamily. We find that although there is limited sequence, identity between OP-1 and TGF-beta 2, they share a common polypeptide, fold. These results establish a basis for proposing the OP-1/TGF-beta 2, fold as the primary structural motif for the TGF-beta superfamily as a, whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has, revealed striking differences that provide insights into how these growth, factors interact with their receptors.

We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.

==About this Structure==

1BMP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1BMP OCA].

1BMP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMP OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Griffith, D.L.]]

[[Category: Griffith, D L.]]

[[Category: Scott, D.L.]]

[[Category: Scott, D L.]]

[[Category: bone]]

[[Category: cartilage]]

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[[Category: transforming growth factor]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 16~~:12:~~05 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:56:52 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1bmp.gif|left|200px]]<br />
+[[Image:1bmp.gif|left|200px]]<br /><applet load="1bmp" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1bmp" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1bmp, resolution 2.8&Aring;" />
 '''BONE MORPHOGENETIC PROTEIN-7'''<br />
 ==Overview==
-We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a, member of the transforming growth factor beta (TGF-beta) superfamily of, proteins and is able to induce new bone formation in vivo. Members of this, superfamily share sequence similarity in their C-terminal regions and are, implicated in embryonic development and adult tissue repair. Our crystal, structure makes possible the structural comparison between two members of, the TGF-beta superfamily. We find that although there is limited sequence, identity between OP-1 and TGF-beta 2, they share a common polypeptide, fold. These results establish a basis for proposing the OP-1/TGF-beta 2, fold as the primary structural motif for the TGF-beta superfamily as a, whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has, revealed striking differences that provide insights into how these growth, factors interact with their receptors.
+We report the three-dimensional structure of osteogenic protein 1 (OP-1, also known as bone morphogenetic protein 7) to 2.8-A resolution. OP-1 is a member of the transforming growth factor beta (TGF-beta) superfamily of proteins and is able to induce new bone formation in vivo. Members of this superfamily share sequence similarity in their C-terminal regions and are implicated in embryonic development and adult tissue repair. Our crystal structure makes possible the structural comparison between two members of the TGF-beta superfamily. We find that although there is limited sequence identity between OP-1 and TGF-beta 2, they share a common polypeptide fold. These results establish a basis for proposing the OP-1/TGF-beta 2 fold as the primary structural motif for the TGF-beta superfamily as a whole. Detailed comparison of the OP-1 and TGF-beta 2 structures has revealed striking differences that provide insights into how these growth factors interact with their receptors.
 ==About this Structure==
-BMP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BMP OCA].
+BMP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BMP OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Griffith, D.L.]]
+[[Category: Griffith, D L.]]
-[[Category: Scott, D.L.]]
+[[Category: Scott, D L.]]
 [[Category: bone]]
 [[Category: cartilage]]
@@ Line 23: / Line 22: @@
 [[Category: transforming growth factor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:12:05 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:56:52 2008''