1f16: Difference between revisions

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[[Image:1f16.gif|left|200px]]
{{Seed}}
[[Image:1f16.png|left|200px]]


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{{STRUCTURE_1f16|  PDB=1f16  |  SCENE=  }}  
{{STRUCTURE_1f16|  PDB=1f16  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX'''
===SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX===




==Overview==
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Apoptosis is stimulated by the insertion of Bax from the cytosol into mitochondrial membranes. The solution structure of Bax, including the putative transmembrane domain at the C terminus, was determined in order to understand the regulation of its subcellular location. Bax consists of 9 alpha helices where the assembly of helices alpha1 through alpha 8 resembles that of the apoptosis inhibitor, Bcl-x(L). The C-terminal alpha 9 helix occupies the hydrophobic pocket proposed previously to mediate heterodimer formation and bioactivity of opposing members of the Bcl-2 family. The Bax structure shows that the orientation of helix alpha 9 provides simultaneous control over its mitochondrial targeting and dimer formation.
The line below this paragraph, {{ABSTRACT_PUBMED_11106734}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 11106734 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11106734}}


==About this Structure==
==About this Structure==
1F16 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F16 OCA].  
1F16 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F16 OCA].  


==Reference==
==Reference==
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[[Category: Youle, R J.]]
[[Category: Youle, R J.]]
[[Category: Helical protein]]
[[Category: Helical protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:46:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:19:45 2008''

Revision as of 23:19, 30 June 2008

File:1f16.png


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1f16, 20 NMR models (default scene)
Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



SOLUTION STRUCTURE OF A PRO-APOPTOTIC PROTEIN BAX

Template:ABSTRACT PUBMED 11106734

About this Structure

1F16 is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structure of Bax: coregulation of dimer formation and intracellular localization., Suzuki M, Youle RJ, Tjandra N, Cell. 2000 Nov 10;103(4):645-54. PMID:11106734

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