1f2h: Difference between revisions

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[[Image:1f2h.gif|left|200px]]
{{Seed}}
[[Image:1f2h.png|left|200px]]


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{{STRUCTURE_1f2h|  PDB=1f2h  |  SCENE=  }}  
{{STRUCTURE_1f2h|  PDB=1f2h  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE TNFR1 ASSOCIATED PROTEIN, TRADD.'''
===SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE TNFR1 ASSOCIATED PROTEIN, TRADD.===




==Overview==
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TRADD is a multifunctional signaling adaptor protein that is recruited to TNFR1 upon ligand binding. The C-terminal of TRADD comprises the "death domain" that is responsible for association of TNFR1 and other death domain-containing proteins such as FADD and RIP. The N-terminal domain (N-TRADD) promotes the recruitment of TRAF2 to TNFR1 by binding to the C-terminal of TRAF2, leading to the activation of JNK/AP1 and NF-kappa B. The solution structure of N-TRADD was determined, revealing a novel protein fold. A combination of NMR, BIAcore, and mutagenesis experiments was used to help identify the site of interaction of N-TRADD with C-TRAF2, providing a framework for future attempts to selectively inhibit the TNF signaling pathways.
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(as it appears on PubMed at http://www.pubmed.gov), where 10911999 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10911999}}


==About this Structure==
==About this Structure==
1F2H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2H OCA].  
1F2H is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2H OCA].  


==Reference==
==Reference==
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[[Category: Xu, G Y.]]
[[Category: Xu, G Y.]]
[[Category: Tnfr-1 associated protein]]
[[Category: Tnfr-1 associated protein]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:48:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:23:36 2008''

Revision as of 23:23, 30 June 2008

File:1f2h.png

Template:STRUCTURE 1f2h

SOLUTION STRUCTURE OF THE N-TERMINAL DOMAIN OF THE TNFR1 ASSOCIATED PROTEIN, TRADD.

Template:ABSTRACT PUBMED 10911999

About this Structure

1F2H is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway., Tsao DH, McDonagh T, Telliez JB, Hsu S, Malakian K, Xu GY, Lin LL, Mol Cell. 2000 Jun;5(6):1051-7. PMID:10911999

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