7p41: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,330,058 edits
No edit summary
Line 1: Line 1:


==Crystal Structure of human mARC1 A165T Variant==
==Crystal Structure of human mARC1 A165T Variant==
<StructureSection load='7p41' size='340' side='right'caption='[[7p41]]' scene=''>
<StructureSection load='7p41' size='340' side='right'caption='[[7p41]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P41 FirstGlance]. <br>
<table><tr><td colspan='2'>[[7p41]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P41 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P41 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p41 OCA], [https://pdbe.org/7p41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p41 RCSB], [https://www.ebi.ac.uk/pdbsum/7p41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p41 ProSAT]</span></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3P:2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>B3P</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EFK:oxidanyl(oxidanylidene)molybdenum'>EFK</scene>, <scene name='pdbligand=MTE:PHOSPHONIC+ACIDMONO-(2-AMINO-5,6-DIMERCAPTO-4-OXO-3,7,8A,9,10,10A-HEXAHYDRO-4H-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-7-YLMETHYL)ESTER'>MTE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6fw2|6fw2]]</div></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MTARC1, MARC1, MOSC1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p41 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p41 OCA], [https://pdbe.org/7p41 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p41 RCSB], [https://www.ebi.ac.uk/pdbsum/7p41 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p41 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/MARC1_HUMAN MARC1_HUMAN]] As a component of an N-hydroxylated prodrug-converting complex required to reduce N-hydroxylated prodrugs, such as benzamidoxime. Also able to reduce N(omega)-hydroxy-L-arginine (NOHA) and N(omega)-hydroxy-N(delta)-methyl-L-arginine (NHAM) into L-arginine and N(delta)-methyl-L-arginine, respectively.<ref>PMID:19053771</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A study recently published in Hepatology Communications provided insights into a variant of MTARC1 protein, which conveys protection against liver disease. Here, we report a crystal structure of the variant protein at near-atomic resolution and compare it to the structure of the wildtype protein.
Letter to the editor: The clinically relevant MTARC1 p.Ala165Thr variant impacts neither the fold nor active site architecture of the human mARC1 protein.,Struwe MA, Clement B, Scheidig A Hepatol Commun. 2022 May 13. doi: 10.1002/hep4.1984. PMID:35560545<ref>PMID:35560545</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7p41" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Scheidig AJ]]
[[Category: Scheidig, A J]]
[[Category: Struwe MA]]
[[Category: Struwe, M A]]
[[Category: Marc]]
[[Category: Metal binding protein]]
[[Category: Molybdenum cofactor]]
[[Category: Molybdenum enzyme]]
[[Category: Molybdopterin]]
[[Category: Pyranopterin]]
Retrieved from "https://proteopedia.org/7p41"