1ktj: Difference between revisions

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<StructureSection load='1ktj' size='340' side='right'caption='[[1ktj]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
<StructureSection load='1ktj' size='340' side='right'caption='[[1ktj]], [[Resolution|resolution]] 2.15&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ktj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Derpt Derpt]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ktj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Dermatophagoides_pteronyssinus Dermatophagoides pteronyssinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KTJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KTJ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktj OCA], [https://pdbe.org/1ktj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktj RCSB], [https://www.ebi.ac.uk/pdbsum/1ktj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktj ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ktj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ktj OCA], [https://pdbe.org/1ktj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ktj RCSB], [https://www.ebi.ac.uk/pdbsum/1ktj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ktj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ALL2_DERPT ALL2_DERPT]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ktj ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ktj ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The crystal structure of the common house mite (Dermatophagoides sp.) Der p 2 allergen was solved at 2.15 A resolution using the MAD phasing technique, and refined to an R-factor of 0.209. The refined atomic model, which reveals an immunoglobulin-like tertiary fold, differs in important ways from the previously described NMR structure, because the two beta-sheets are significantly further apart and create an internal cavity, which is occupied by a hydrophobic ligand. This interaction is structurally reminiscent of the binding of a prenyl group by a regulatory protein, the Rho guanine nucleotide exchange inhibitor. The crystal structure suggests that binding of non-polar molecules may be essential to the physiological function of the Der p 2 protein.
The crystal structure of a major dust mite allergen Der p 2, and its biological implications.,Derewenda U, Li J, Derewenda Z, Dauter Z, Mueller GA, Rule GS, Benjamin DC J Mol Biol. 2002 Apr 19;318(1):189-97. PMID:12054778<ref>PMID:12054778</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 1ktj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Derpt]]
[[Category: Dermatophagoides pteronyssinus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Benjamin, D C]]
[[Category: Benjamin DC]]
[[Category: Dauter, Z]]
[[Category: Dauter Z]]
[[Category: Derewenda, U]]
[[Category: Derewenda U]]
[[Category: Derewenda, Z]]
[[Category: Derewenda Z]]
[[Category: Li, J]]
[[Category: Li J]]
[[Category: Mueller, G A]]
[[Category: Mueller GA]]
[[Category: Rule, G S]]
[[Category: Rule GS]]
[[Category: Allergen]]
[[Category: Asthma]]
[[Category: Hydrophobic cavity]]
[[Category: Immunoglobulin fold]]

Revision as of 08:03, 3 April 2024

X-ray Structure Of Der P 2, The Major House Dust Mite Allergen

1ktj, resolution 2.15Å

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