1f32: Difference between revisions

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[[Image:1f32.gif|left|200px]]
{{Seed}}
[[Image:1f32.png|left|200px]]


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{{STRUCTURE_1f32|  PDB=1f32  |  SCENE=  }}  
{{STRUCTURE_1f32|  PDB=1f32  |  SCENE=  }}  


'''CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3'''
===CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3===




==Overview==
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The three-dimensional structures of pepsin inhibitor-3 (PI-3) from Ascaris suum and of the complex between PI-3 and porcine pepsin at 1. 75 A and 2.45 A resolution, respectively, have revealed the mechanism of aspartic protease inhibition by this unique inhibitor. PI-3 has a new fold consisting of two domains, each comprising an antiparallel beta-sheet flanked by an alpha-helix. In the enzyme-inhibitor complex, the N-terminal beta-strand of PI-3 pairs with one strand of the 'active site flap' (residues 70-82) of pepsin, thus forming an eight-stranded beta-sheet that spans the two proteins. PI-3 has a novel mode of inhibition, using its N-terminal residues to occupy and therefore block the first three binding pockets in pepsin for substrate residues C-terminal to the scissile bond (S1'-S3'). The molecular structure of the pepsin-PI-3 complex suggests new avenues for the rational design of proteinaceous aspartic proteinase inhibitors.
The line below this paragraph, {{ABSTRACT_PUBMED_10932249}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_10932249}}


==About this Structure==
==About this Structure==
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[[Category: Petersen, J F.]]
[[Category: Petersen, J F.]]
[[Category: Proteinase inhibitor]]
[[Category: Proteinase inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:49:59 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:32:10 2008''

Revision as of 23:32, 30 June 2008

File:1f32.png

Template:STRUCTURE 1f32

CRYSTAL STRUCTURE OF ASCARIS PEPSIN INHIBITOR-3

Template:ABSTRACT PUBMED 10932249

About this Structure

1F32 is a Single protein structure of sequence from Ascaris suum. Full crystallographic information is available from OCA.

Reference

Structural basis for the inhibition of porcine pepsin by Ascaris pepsin inhibitor-3., Ng KK, Petersen JF, Cherney MM, Garen C, Zalatoris JJ, Rao-Naik C, Dunn BM, Martzen MR, Peanasky RJ, James MN, Nat Struct Biol. 2000 Aug;7(8):653-7. PMID:10932249

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