1f3j: Difference between revisions

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[[Image:1f3j.jpg|left|200px]]
{{Seed}}
[[Image:1f3j.png|left|200px]]


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{{STRUCTURE_1f3j|  PDB=1f3j  |  SCENE=  }}  
{{STRUCTURE_1f3j|  PDB=1f3j  |  SCENE=  }}  


'''HISTOCOMPATIBILITY ANTIGEN I-AG7'''
===HISTOCOMPATIBILITY ANTIGEN I-AG7===




==Overview==
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We have determined the crystal structure of I-Ag7, an integral component in murine type I diabetes development. Several features distinguish I-Ag7 from other non-autoimmune-associated MHC class II molecules, including novel peptide and heterodimer pairing interactions. The binding groove of I-Ag7 is unusual at both terminal ends, with a potentially solvent-exposed channel at the base of the P1 pocket and a widened entrance to the P9 pocket. Peptide binding studies with variants of the hen egg lysozyme I-Ag7 epitope HEL(11-25) support a comprehensive structure-based I-Ag7 binding motif. Residues critical for T cell recognition were investigated with a panel of HEL(11-25)-restricted clones, which uncovered P1 anchor-dependent structural variations. These results establish a framework for future experiments directed at understanding the role of I-Ag7 in autoimmunity.
The line below this paragraph, {{ABSTRACT_PUBMED_10894169}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10894169 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10894169}}


==About this Structure==
==About this Structure==
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[[Category: Mhc]]
[[Category: Mhc]]
[[Category: Peptide complex]]
[[Category: Peptide complex]]
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