7p8w: Difference between revisions
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==Human erythrocyte catalase cryoEM== | ==Human erythrocyte catalase cryoEM== | ||
<StructureSection load='7p8w' size='340' side='right'caption='[[7p8w]]' scene=''> | <StructureSection load='7p8w' size='340' side='right'caption='[[7p8w]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P8W FirstGlance]. <br> | <table><tr><td colspan='2'>[[7p8w]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P8W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P8W FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p8w OCA], [https://pdbe.org/7p8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p8w RCSB], [https://www.ebi.ac.uk/pdbsum/7p8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p8w ProSAT]</span></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAT ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Catalase Catalase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.11.1.6 1.11.1.6] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p8w OCA], [https://pdbe.org/7p8w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p8w RCSB], [https://www.ebi.ac.uk/pdbsum/7p8w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p8w ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[[https://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN]] Defects in CAT are the cause of acatalasemia (ACATLAS) [MIM:[https://omim.org/entry/614097 614097]]. A metabolic disorder characterized by absence of catalase activity in red cells and is often associated with ulcerating oral lesions.<ref>PMID:2308162</ref> | |||
== Function == | |||
[[https://www.uniprot.org/uniprot/CATA_HUMAN CATA_HUMAN]] Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells.<ref>PMID:7882369</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Catalase]] | |||
[[Category: Human]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chen S]] | [[Category: Chen, S]] | ||
[[Category: Henderson R]] | [[Category: Henderson, R]] | ||
[[Category: Li J]] | [[Category: Li, J]] | ||
[[Category: Vinothkumar | [[Category: Vinothkumar, K R]] | ||
[[Category: Human erythrocyte catalase cryoem]] | |||
[[Category: Oxidoreductase]] | |||
