1btr: Difference between revisions

[[Image:1btr.gif|left|200px]]<br />

<applet load="1btr" size="450" color="white" frame="true" align="right" spinBox="true"  

We have studied the structures of synthetic peptides which correspond to, the proposed first and second membrane-spanning segments of the human red, cell anion transporter (band 3). The peptides, which were acetylated at, their N-termini and amidated at the C-termini, comprise the 20 amino acids, of residues 405-424 and 21 amino acids of residues 436-456 of the human, band 3 sequence. The solution structures of the peptides in, trifluoroethanol were studied by two-dimensional NMR spectroscopy., Characteristic NOEs were observed indicating that the peptides adopted a, predominantly alpha-helical structure in trifluoroethanol solution., Dynamical simulated annealing using the program XPLOR was employed for the, structure calculations. The amide exchange rates in trifluoroethanol have, also been measured and are consistent with an alpha-helical structure for, the peptides.

Known diseases associated with this structure: Acanthocytosis, one form OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109270 109270]], Blood group, Diego OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109270 109270]], Blood group, Waldner OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109270 109270]], Blood group, Wright OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109270 109270]], Diabetes insipidus, nephrogenic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300538 300538]], Elliptocytosis, Malaysian-Melanesian type OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109270 109270]], Hemolytic anemia due to band 3 defect defect OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109270 109270]], Nephrogenic syndrome of inappropriate antidiuresis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=300538 300538]], OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id= ]]109270, Renal tubular acidosis, distal, 179800 OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109270 109270]], Spherocytosis, hereditary OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=109270 109270]]

1BTR is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ACE and NH2 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BTR OCA].  

[[Category: Bloomberg, G.B.]]

[[Category: Dempsey, C.E.]]

[[Category: Gargaro, A.R.]]

[[Category: Tanner, M.J.A.]]

''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:14:20 2007''