1f5u: Difference between revisions

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[[Image:1f5u.gif|left|200px]]
{{Seed}}
[[Image:1f5u.png|left|200px]]


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{{STRUCTURE_1f5u|  PDB=1f5u  |  SCENE=  }}  
{{STRUCTURE_1f5u|  PDB=1f5u  |  SCENE=  }}  


'''SOLUTION STRUCTURE OF THE KISSING DIMER OF H3 GACG STEM-LOOP IN THE 5'-END DIMERIZATION SIGNAL OF MOLONEY MURINE LEUKEMIA VIRUS GENOMIC RNA'''
===SOLUTION STRUCTURE OF THE KISSING DIMER OF H3 GACG STEM-LOOP IN THE 5'-END DIMERIZATION SIGNAL OF MOLONEY MURINE LEUKEMIA VIRUS GENOMIC RNA===




==Overview==
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The dimerization of viral RNA through noncovalent interactions at their 5' ends is a key step in the life cycle of retroviruses. In Moloney murine leukemia virus, three stem-loops are important in this process. One is a self-complementary tetraloop (H1), but the other two stem-loops (H2, H3) contain highly conserved GACG tetraloops that are not self-complementary sequences. Using two-dimensional NMR, we determined the structure of the H3 stem-loop. Surprisingly, it forms a stable, homodimeric kissing complex through only two intermolecular G small middle dotC base pairs. Cross-strand interactions of the adenines adjacent to the intermolecular G small middle dotC base pairs, plus unusual strong electrostatic interactions around the base pairs, contribute to the unexpected stability. This structure shows how even stem-loops without self-complementary sequences can facilitate the intermolecular recognition between two identical RNAs, and thus initiate dimerization and encapsidation of retroviral RNAs.
The line below this paragraph, {{ABSTRACT_PUBMED_10931958}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 10931958 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10931958}}


==About this Structure==
==About this Structure==
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5U OCA].  
Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F5U OCA].  


==Reference==
==Reference==
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[[Category: Stem-loop]]
[[Category: Stem-loop]]
[[Category: Tetraloop]]
[[Category: Tetraloop]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:56:14 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:44:52 2008''

Revision as of 23:44, 30 June 2008

File:1f5u.png

Template:STRUCTURE 1f5u

SOLUTION STRUCTURE OF THE KISSING DIMER OF H3 GACG STEM-LOOP IN THE 5'-END DIMERIZATION SIGNAL OF MOLONEY MURINE LEUKEMIA VIRUS GENOMIC RNA

Template:ABSTRACT PUBMED 10931958

About this Structure

Full experimental information is available from OCA.

Reference

A retroviral RNA kissing complex containing only two G.C base pairs., Kim CH, Tinoco I Jr, Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9396-401. PMID:10931958

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