1by2: Difference between revisions

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[[Image:1by2.gif|left|200px]]<br />

[[Image:1by2.gif|left|200px]]<br /><applet load="1by2" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1by2" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1by2, resolution 2.00Å" />

'''STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN'''<br />

==Overview==

Scavenger receptor cysteine-rich (SRCR) domains are found widely in cell, surface molecules and in some secreted proteins, where they are thought to, mediate ligand binding. We have determined the crystal structure at 2.0 A, resolution of the SRCR domain of Mac-2 binding protein (M2BP), a, tumor-associated antigen and matrix protein. The structure reveals a, curved six-stranded beta-sheet cradling an alpha-helix. Structure-based, sequence alignment demonstrates that the M2BP SRCR domain is a valid, template for the entire SRCR protein superfamily. This allows an, interpretation of previous mutagenesis data on ligand binding to the, lymphocyte receptor CD6.

Scavenger receptor cysteine-rich (SRCR) domains are found widely in cell surface molecules and in some secreted proteins, where they are thought to mediate ligand binding. We have determined the crystal structure at 2.0 A resolution of the SRCR domain of Mac-2 binding protein (M2BP), a tumor-associated antigen and matrix protein. The structure reveals a curved six-stranded beta-sheet cradling an alpha-helix. Structure-based sequence alignment demonstrates that the M2BP SRCR domain is a valid template for the entire SRCR protein superfamily. This allows an interpretation of previous mutagenesis data on ligand binding to the lymphocyte receptor CD6.

==About this Structure==

1BY2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1BY2 OCA].

1BY2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY2 OCA].

==Reference==

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[[Category: tumour-associated antigen]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov~~ 12 16:15:20 ~~2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:00:20 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1by2.gif|left|200px]]<br />
+[[Image:1by2.gif|left|200px]]<br /><applet load="1by2" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1by2" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1by2, resolution 2.00&Aring;" />
 '''STRUCTURE OF M2BP SCAVENGER RECEPTOR CYSTEINE-RICH DOMAIN'''<br />
 ==Overview==
-Scavenger receptor cysteine-rich (SRCR) domains are found widely in cell, surface molecules and in some secreted proteins, where they are thought to, mediate ligand binding. We have determined the crystal structure at 2.0 A, resolution of the SRCR domain of Mac-2 binding protein (M2BP), a, tumor-associated antigen and matrix protein. The structure reveals a, curved six-stranded beta-sheet cradling an alpha-helix. Structure-based, sequence alignment demonstrates that the M2BP SRCR domain is a valid, template for the entire SRCR protein superfamily. This allows an, interpretation of previous mutagenesis data on ligand binding to the, lymphocyte receptor CD6.
+Scavenger receptor cysteine-rich (SRCR) domains are found widely in cell surface molecules and in some secreted proteins, where they are thought to mediate ligand binding. We have determined the crystal structure at 2.0 A resolution of the SRCR domain of Mac-2 binding protein (M2BP), a tumor-associated antigen and matrix protein. The structure reveals a curved six-stranded beta-sheet cradling an alpha-helix. Structure-based sequence alignment demonstrates that the M2BP SRCR domain is a valid template for the entire SRCR protein superfamily. This allows an interpretation of previous mutagenesis data on ligand binding to the lymphocyte receptor CD6.
 ==About this Structure==
-BY2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BY2 OCA].
+BY2 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BY2 OCA].
 ==Reference==
@@ Line 24: / Line 23: @@
 [[Category: tumour-associated antigen]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 16:15:20 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 12:00:20 2008''