1ql6: Difference between revisions

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<StructureSection load='1ql6' size='340' side='right'caption='[[1ql6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='1ql6' size='340' side='right'caption='[[1ql6]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ql6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/European_rabbit European rabbit]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QL6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ql6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QL6 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1phk|1phk]], [[2phk|2phk]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Phosphorylase_kinase Phosphorylase kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.19 2.7.11.19] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ql6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ql6 OCA], [https://pdbe.org/1ql6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ql6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ql6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ql6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ql6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ql6 OCA], [https://pdbe.org/1ql6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ql6 RCSB], [https://www.ebi.ac.uk/pdbsum/1ql6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ql6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PHKG1_RABIT PHKG1_RABIT]] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.<ref>PMID:8454596</ref> <ref>PMID:8999860</ref>
[https://www.uniprot.org/uniprot/PHKG1_RABIT PHKG1_RABIT] Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. In vitro, phosphorylates PYGM, TNNI3, MAPT/TAU, GAP43 and NRGN/RC3.<ref>PMID:8454596</ref> <ref>PMID:8999860</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: European rabbit]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Phosphorylase kinase]]
[[Category: Oryctolagus cuniculus]]
[[Category: Johnson, L N]]
[[Category: Johnson LN]]
[[Category: Lowe, E D]]
[[Category: Lowe ED]]
[[Category: Noble, M E.M]]
[[Category: Noble MEM]]
[[Category: Oikonomakos, N G]]
[[Category: Oikonomakos NG]]
[[Category: Owen, D J]]
[[Category: Owen DJ]]
[[Category: Skamnaki, V T]]
[[Category: Skamnaki VT]]
[[Category: Atp-binding]]
[[Category: Calmodulin-binding]]
[[Category: Glycogen metabolism]]
[[Category: Kinase]]
[[Category: Serine/threonine-protein]]
[[Category: Transferase]]
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