Structure superposition tools: Difference between revisions
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The statistical significance of a structural superposition, relative to a superposition of random sequence-nonredundant structures in the [[PDB]], is usually measured with a '''[http://en.wikipedia.org/wiki/Standard_score z-score]'''. The z-score is the distance, in standard deviations, between the observed alignment RMSD and the mean RMSD for random pairs of the same length, with the same or fewer gaps. Z-scores less than 2 are considered to lack statistical significance. | The statistical significance of a structural superposition, relative to a superposition of random sequence-nonredundant structures in the [[PDB]], is usually measured with a '''[http://en.wikipedia.org/wiki/Standard_score z-score]'''. The z-score is the distance, in standard deviations, between the observed alignment RMSD and the mean RMSD for random pairs of the same length, with the same or fewer gaps. Z-scores less than 2 are considered to lack statistical significance. | ||
When the models being compared have substantial differences, and especially if they have multiple domains, different estimates of the closenss of fit have been employed, notably in [[CASP]]. | When the models being compared have substantial differences, and especially if they have multiple domains, different estimates of the closenss of fit have been employed, notably in [[CASP]]. One of these is the ''global distance test total score'', or [[Calculating_GDT_TS|GDT_TS]]. See also [[Theoretical models]]. | ||
==Visualizing Structural Alignments== | ==Visualizing Structural Alignments== | ||
