7pp9: Difference between revisions

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'''Unreleased structure'''


The entry 7pp9 is ON HOLD
==Three dimensional structure of human carbonic anhydrase XII in complex with sulfonamide==
 
<StructureSection load='7pp9' size='340' side='right'caption='[[7pp9]], [[Resolution|resolution]] 2.34&Aring;' scene=''>
Authors: Leitans, J., Tars, K., Dvinskis, E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7pp9]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PP9 FirstGlance]. <br>
Description: Three dimensional structure of human carbonic anhydrase XII in complex with sulfonamide
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7VZ:methyl+2-chloranyl-4-cyclohexylsulfanyl-5-sulfamoyl-benzoate'>7VZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pp9 OCA], [https://pdbe.org/7pp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pp9 RCSB], [https://www.ebi.ac.uk/pdbsum/7pp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pp9 ProSAT]</span></td></tr>
[[Category: Dvinskis, E]]
</table>
[[Category: Leitans, J]]
== Disease ==
[[Category: Tars, K]]
[[https://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Defects in CA12 are the cause of hyperchlorhidrosis isolated (HCHLH) [MIM:[https://omim.org/entry/143860 143860]]. HCHLH is a disorder characterized by excessive sweating and increased sweat chloride levels. Affected individuals suffer from episodes of hyponatremic dehydration and report increased amounts of visible salt precipitates in sweat.<ref>PMID:21035102</ref>
== Function ==
[[https://www.uniprot.org/uniprot/CAH12_HUMAN CAH12_HUMAN]] Reversible hydration of carbon dioxide.
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Dvinskis E]]
[[Category: Leitans J]]
[[Category: Tars K]]
Retrieved from "https://proteopedia.org/7pp9"