7s1c: Difference between revisions
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==Crystal structure of E.coli DsbA in complex with compound MIPS-0001897 (compound 1)== | |||
<StructureSection load='7s1c' size='340' side='right'caption='[[7s1c]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7s1c]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7S1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7S1C FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5VA:~{N}-methyl-1-(3-thiophen-3-ylphenyl)methanamine'>5VA</scene>, <scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7s1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7s1c OCA], [https://pdbe.org/7s1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7s1c RCSB], [https://www.ebi.ac.uk/pdbsum/7s1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7s1c ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/DSBA_ECOLI DSBA_ECOLI] Required for disulfide bond formation in some periplasmic proteins such as PhoA or OmpA. Acts by transferring its disulfide bond to other proteins and is reduced in the process. DsbA is reoxidized by DsbB. Required for pilus biogenesis. PhoP-regulated transcription is redox-sensitive, being activated when the periplasm becomes more reducing (deletion of dsbA/dsbB, treatment with dithiothreitol). MgrB acts between DsbA/DsbB and PhoP/PhoQ in this pathway.<ref>PMID:1429594</ref> <ref>PMID:22267510</ref> | ||
[[Category: | == References == | ||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Heras B]] | |||
[[Category: Martin JL]] | |||
[[Category: Scanlon MJ]] | |||
[[Category: Sharma P]] | |||
Revision as of 06:41, 8 February 2023
Crystal structure of E.coli DsbA in complex with compound MIPS-0001897 (compound 1)
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