1f8z: Difference between revisions

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[[Image:1f8z.~~gif~~|left|200px]]

[[Image:1f8z.png|left|200px]]

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~~'''~~NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR~~'''~~

===NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR===

~~==Overview==~~

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The ~~sixth ligand-binding module of~~ the ~~low-density lipoprotein receptor contributes~~ to the ~~binding of apolipoprotein B100-containing lipoproteins~~. ~~1H NMR spectroscopy~~, DYANA and X-PLOR structure calculations were used to determine that this module has a well defined structure with a backbone conformation similar to other modules. Structures from calculations that simulated the ~~presence of a calcium ion showed increased resolution without large increases in energy, increased deviations from idealised geometry or violations of experimental constraints~~. ~~Investigation of the surface properties of this module indicates there are significant differences from the fifth module, which binds apolipoprotein E~~-~~containing lipoproteins in addition to apolipoprotein B100~~-~~containing lipoproteins.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10981718}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10981718 is the PubMed ID number.

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==About this Structure==

1F8Z is a [[Single protein]] structure. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8Z OCA].

1F8Z is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8Z OCA].

==Reference==

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[[Category: Ldl receptor]]

[[Category: Ligand-binding domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:02:44 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:53:18 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1f8z.gif|left|200px]]
+{{Seed}}
+[[Image:1f8z.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_1f8z|  PDB=1f8z  |  SCENE=  }}
-'''NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR'''
+===NMR STRUCTURE OF THE SIXTH LIGAND-BINDING MODULE OF THE LDL RECEPTOR===
-==Overview==
+<!--
-The sixth ligand-binding module of the low-density lipoprotein receptor contributes to the binding of apolipoprotein B100-containing lipoproteins. 1H NMR spectroscopy, DYANA and X-PLOR structure calculations were used to determine that this module has a well defined structure with a backbone conformation similar to other modules. Structures from calculations that simulated the presence of a calcium ion showed increased resolution without large increases in energy, increased deviations from idealised geometry or violations of experimental constraints. Investigation of the surface properties of this module indicates there are significant differences from the fifth module, which binds apolipoprotein E-containing lipoproteins in addition to apolipoprotein B100-containing lipoproteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_10981718}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10981718 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10981718}}
 ==About this Structure==
-F8Z is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8Z OCA].
+F8Z is a [[Single protein]] structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F8Z OCA].
 ==Reference==
@@ Line 29: / Line 33: @@
 [[Category: Ldl receptor]]
 [[Category: Ligand-binding domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:02:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 02:53:18 2008''