AlphaFold: Difference between revisions
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* '''A structural biology community assessment of AlphaFold 2 applications.''' | * '''A structural biology community assessment of AlphaFold 2 applications.''' | ||
: Akdel et al. 2021 | : Akdel et al., 2021 | ||
: https://biorxiv.org/cgi/content/short/2021.09.26.461876 | : https://biorxiv.org/cgi/content/short/2021.09.26.461876 | ||
: Several findings: | : Several findings: | ||
:: AlphaFold 2 can often predict the correct homo-oligomer structure when given the correct oligomeric state (number of copies in complex); however, it's not always able to predict the correct oligomeric state ''a priori''. | :: AlphaFold 2 can often predict the correct homo-oligomer structure when given the correct oligomeric state (number of copies in complex); however, it's not always able to predict the correct oligomeric state ''a priori''. | ||
:: "AF2 models can be used across diverse applications equally well compared to experimentally determined structures, when the confidence metrics are critically considered." | :: "AF2 models can be used across diverse applications equally well compared to experimentally determined structures, when the confidence metrics are critically considered." | ||
