1faf: Difference between revisions

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[[Image:1faf.gif|left|200px]]
{{Seed}}
[[Image:1faf.png|left|200px]]


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{{STRUCTURE_1faf|  PDB=1faf  |  SCENE=  }}  
{{STRUCTURE_1faf|  PDB=1faf  |  SCENE=  }}  


'''NMR STRUCTURE OF THE N-TERMINAL J DOMAIN OF MURINE POLYOMAVIRUS T ANTIGENS.'''
===NMR STRUCTURE OF THE N-TERMINAL J DOMAIN OF MURINE POLYOMAVIRUS T ANTIGENS.===




==Overview==
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The NMR structure of the N-terminal, DnaJ-like domain of murine polyomavirus tumor antigens (PyJ) has been determined to high precision, with root mean square deviations to the mean structure of 0.38 A for backbone atoms and 0.94 A for all heavy atoms of ordered residues 5-41 and 50-69. PyJ possesses a three-helix fold, in which anti-parallel helices II and III are bridged by helix I, similar to the four-helix fold of the J domains of DnaJ and human DnaJ-1. PyJ differs significantly in the lengths of N terminus, helix I, and helix III. The universally conserved HPD motif appears to form a His-Pro C-cap of helix II. Helix I features a stabilizing Schellman C-cap that is probably conserved universally among J domains. On the helix II surface where positive charges of other J domains have been implicated in binding of hsp70s, PyJ contains glutamine residues. Nonetheless, chimeras that replace the J domain of DnaJ with PyJ function like wild-type DnaJ in promoting growth of Escherichia coli. This activity can be modulated by mutations of at least one of these glutamines. T antigen mutations reported to impair cellular transformation by the virus, presumably via interactions with PP2A, cluster in the hydrophobic folding core and at the extreme N terminus, remote from the HPD loop.
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{{ABSTRACT_PUBMED_10950962}}


==About this Structure==
==About this Structure==
1FAF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Murine_polyomavirus Murine polyomavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FAF OCA].  
1FAF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Murine_polyomavirus Murine polyomavirus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1FAF OCA].  


==Reference==
==Reference==
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[[Category: Hpd motif]]
[[Category: Hpd motif]]
[[Category: J domain]]
[[Category: J domain]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 16:06:03 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 02:57:20 2008''

Revision as of 23:57, 30 June 2008

File:1faf.png

Template:STRUCTURE 1faf

NMR STRUCTURE OF THE N-TERMINAL J DOMAIN OF MURINE POLYOMAVIRUS T ANTIGENS.

Template:ABSTRACT PUBMED 10950962

About this Structure

1FAF is a Single protein structure of sequence from Murine polyomavirus. Full experimental information is available from OCA.

Reference

NMR structure of the N-terminal J domain of murine polyomavirus T antigens. Implications for DnaJ-like domains and for mutations of T antigens., Berjanskii MV, Riley MI, Xie A, Semenchenko V, Folk WR, Van Doren SR, J Biol Chem. 2000 Nov 17;275(46):36094-103. PMID:10950962

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