6xcu: Difference between revisions

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==NMR structure of Ost4V23D, a critical mutant of Ost4, in DPC micelles==

== Structural highlights ==

<table><tr><td colspan='2'>[[6xcu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/~~Baker's_yeast Baker's yeast~~]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCU OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6XCU FirstGlance].

<table><tr><td colspan='2'>[[6xcu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_YJM789 Saccharomyces cerevisiae YJM789]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCU OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=6XCU FirstGlance].

</td></tr><tr id='gene'><td class="sblockLbl">[[Gene|Gene:]]</td><td class="sblockDat">OST4, SCY_0690 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=307796 Baker's yeast])</td></tr>

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6xcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcu OCA], [https://pdbe.org/6xcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcu RCSB], [https://www.ebi.ac.uk/pdbsum/6xcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcu ProSAT]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[https://en.wikipedia.org/wiki/Dolichyl-diphosphooligosaccharide--protein_glycotransferase Dolichyl-diphosphooligosaccharide--protein glycotransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.18 2.4.99.18] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=6xcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcu OCA], [https://pdbe.org/6xcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcu RCSB], [https://www.ebi.ac.uk/pdbsum/6xcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcu ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/OST4_YEAST OST4_YEAST] Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. OST4 is required for recruitment of OST3 or OST6 to the OST complex. It is essential for cell growth at 37 but not at 25 degrees Celsius.

== Publication Abstract from PubMed ==

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__TOC__

</StructureSection>

~~[[Category: Baker's yeast]]~~

~~[[Category: Dolichyl-diphosphooligosaccharide--protein glycotransferase]]~~

[[Category: Large Structures]]

[[Category: ~~Chaudhary, B P~~]]

[[Category: Saccharomyces cerevisiae YJM789]]

[[Category: ~~Membrane protein]]~~

[[Category: Chaudhary BP]]

~~[[Category: Transferase~~]]

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@@ Line 1: / Line 1: @@
 ==NMR structure of Ost4V23D, a critical mutant of Ost4, in DPC micelles==
-<StructureSection load='6xcu' size='340' side='right'caption='[[6xcu]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='6xcu' size='340' side='right'caption='[[6xcu]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[6xcu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XCU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[6xcu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_YJM789 Saccharomyces cerevisiae YJM789]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6XCU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6XCU FirstGlance]. <br>
-</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OST4, SCY_0690 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=307796 Baker's yeast])</td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcu OCA], [https://pdbe.org/6xcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcu RCSB], [https://www.ebi.ac.uk/pdbsum/6xcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcu ProSAT]</span></td></tr>
-<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Dolichyl-diphosphooligosaccharide--protein_glycotransferase Dolichyl-diphosphooligosaccharide--protein glycotransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.99.18 2.4.99.18] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6xcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6xcu OCA], [https://pdbe.org/6xcu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6xcu RCSB], [https://www.ebi.ac.uk/pdbsum/6xcu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6xcu ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/OST4_YEAST OST4_YEAST] Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. OST4 is required for recruitment of OST3 or OST6 to the OST complex. It is essential for cell growth at 37 but not at 25 degrees Celsius.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Baker's yeast]]
-[[Category: Dolichyl-diphosphooligosaccharide--protein glycotransferase]]
 [[Category: Large Structures]]
-[[Category: Chaudhary, B P]]
+[[Category: Saccharomyces cerevisiae YJM789]]
-[[Category: Membrane protein]]
+[[Category: Chaudhary BP]]
-[[Category: Transferase]]