1fbn: Difference between revisions

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[[Image:1fbn.~~gif~~|left|200px]]

[[Image:1fbn.png|left|200px]]

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~~'''~~CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A~~'''~~

===CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A===

~~==Overview==~~

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~~Fibrillarin is a phylogenetically conserved protein essential for efficient processing of pre-rRNA through its association with a class of small nucleolar RNAs during ribosomal biogenesis.~~ The ~~protein is~~ the ~~antigen for~~ the ~~autoimmune disease scleroderma. Here we report the crystal structure of the fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile,~~ at 1.~~6 A resolution~~. ~~The structure consists of two domains~~, ~~with a novel fold in~~ the ~~N-terminal region and a methyltransferase-like domain in the C-terminal region~~. ~~Mapping temperature~~-~~sensitive mutations found in yeast fibrillarin Nop1 to the Methanococcus homologue structure reveals that many of the mutations cluster in the core of the methyltransferase~~-~~like domain.~~

The line below this paragraph, {{ABSTRACT_PUBMED_10654930}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 10654930 is the PubMed ID number.

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==About this Structure==

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[[Category: Snornp]]

[[Category: Structural genomic]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri May~~ ~~2 16~~:08:18 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 03:00:18 2008''

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-[[Image:1fbn.gif|left|200px]]
+{{Seed}}
+[[Image:1fbn.png|left|200px]]
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 {{STRUCTURE_1fbn|  PDB=1fbn  |  SCENE=  }}
-'''CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A'''
+===CRYSTAL STRUCTURE OF A FIBRILLARIN HOMOLOGUE FROM METHANOCOCCUS JANNASCHII, A HYPERTHERMOPHILE, AT 1.6 A===
-==Overview==
+<!--
-Fibrillarin is a phylogenetically conserved protein essential for efficient processing of pre-rRNA through its association with a class of small nucleolar RNAs during ribosomal biogenesis. The protein is the antigen for the autoimmune disease scleroderma. Here we report the crystal structure of the fibrillarin homologue from Methanococcus jannaschii, a hyperthermophile, at 1.6 A resolution. The structure consists of two domains, with a novel fold in the N-terminal region and a methyltransferase-like domain in the C-terminal region. Mapping temperature-sensitive mutations found in yeast fibrillarin Nop1 to the Methanococcus homologue structure reveals that many of the mutations cluster in the core of the methyltransferase-like domain.
+The line below this paragraph, {{ABSTRACT_PUBMED_10654930}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 10654930 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_10654930}}
 ==About this Structure==
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 [[Category: Snornp]]
 [[Category: Structural genomic]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 16:08:18 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul  1 03:00:18 2008''